Flavokawain b is a lipid of Polyketides (PK) class. Flavokawain b is associated with abnormalities such as Helminthiasis. The involved functions are known as Cell Death and MAPK Signaling Pathway. Flavokawain b often locates in Blood, Entire bony skeleton and Integumentary system.
To understand associated biological information of Flavokawain b, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Flavokawain b is suspected in Helminthiasis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Flavokawain b
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| He Q et al. | Adenosine 5'-monophosphate-activated protein kinase-dependent mTOR pathway is involved in flavokawain B-induced autophagy in thyroid cancer cells. | 2018 | Cancer Sci. | pmid:29908094 |
| Lee JJ et al. | The Combination of Flavokawain B and Daunorubicin Induces Apoptosis in Human Myeloid Leukemic Cells by Modifying NF-κB. | 2018 | Anticancer Res. | pmid:29715098 |
| Abu Bakar A et al. | Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines. | 2018 | Molecules | pmid:29518053 |
| Rossette MC et al. | The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B. | 2017 | Phytother Res | pmid:28816367 |
| Thieury C et al. | Mechanisms of action and structure-activity relationships of cytotoxic flavokawain derivatives. | 2017 | Bioorg. Med. Chem. | pmid:28214231 |
| Malami I et al. | Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells. | 2017 | PLoS ONE | pmid:28103302 |
| Chang CT et al. | Chalcone flavokawain B induces autophagic-cell death via reactive oxygen species-mediated signaling pathways in human gastric carcinoma and suppresses tumor growth in nude mice. | 2017 | Arch. Toxicol. | pmid:28374157 |
| Yeap SK et al. | Gene Expression Analysis Reveals the Concurrent Activation of Proapoptotic and Antioxidant-Defensive Mechanisms in Flavokawain B-Treated Cervical Cancer HeLa Cells. | 2017 | Integr Cancer Ther | pmid:27458249 |
| Rodrigues DF et al. | Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd. | 2017 | Planta Med. | pmid:27442262 |
| Malami I et al. | In Silico Discovery of Potential Uridine-Cytidine Kinase 2 Inhibitors from the Rhizome of Alpinia mutica. | 2016 | Molecules | pmid:27070566 |
| Abu N et al. | Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro. | 2016 | BMC Complement Altern Med | pmid:26922065 |
| Pinner KD et al. | Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes. | 2016 | Pharm Biol | pmid:26789234 |
| Liu H et al. | Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives. | 2016 | J Enzyme Inhib Med Chem | pmid:26186269 |
| Abu N et al. | In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice. | 2015 | Drug Des Devel Ther | pmid:25834398 |
| Zenger K et al. | Biotransformation of Flavokawains A, B, and C, Chalcones from Kava (Piper methysticum), by Human Liver Microsomes. | 2015 | J. Agric. Food Chem. | pmid:26123050 |
| Tang YL et al. | Flavokawain B inhibits the growth of acute lymphoblastic leukemia cells via p53 and caspase-dependent mechanisms. | 2015 | Leuk. Lymphoma | pmid:25641429 |
| Jeong HJ et al. | Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs. | 2015 | Bioorg. Med. Chem. Lett. | pmid:25597012 |
| Narayanapillai SC et al. | Flavokawains a and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice. | 2014 | Chem. Res. Toxicol. | pmid:25185080 |
| Liu HR et al. | Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B. | 2014 | Bioorg. Med. Chem. Lett. | pmid:25205193 |
| Lebot V et al. | Detection of flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC). | 2014 | Food Chem | pmid:24423570 |