Flavokawain b is a lipid of Polyketides (PK) class. Flavokawain b is associated with abnormalities such as Helminthiasis. The involved functions are known as Cell Death and MAPK Signaling Pathway. Flavokawain b often locates in Blood, Entire bony skeleton and Integumentary system.
To understand associated biological information of Flavokawain b, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Flavokawain b is suspected in Helminthiasis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Flavokawain b
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Narayanapillai SC et al. | Flavokawains a and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice. | 2014 | Chem. Res. Toxicol. | pmid:25185080 |
| Lebot V et al. | Detection of flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC). | 2014 | Food Chem | pmid:24423570 |
| Ji T et al. | Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis. | 2013 | Mol. Cancer | pmid:23764122 |
| Kamaldin MN et al. | Peripheral antinociception of a chalcone, flavokawin B and possible involvement of the nitric oxide/cyclic guanosine monophosphate/potassium channels pathway. | 2013 | Molecules | pmid:23612473 |
| Lin E et al. | Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo. | 2012 | J. Nutr. Biochem. | pmid:21543203 |
| Feroz SR et al. | Multispectroscopic and molecular modeling approach to investigate the interaction of flavokawain B with human serum albumin. | 2012 | J. Agric. Food Chem. | pmid:22624666 |
| Hseu YC et al. | The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. | 2012 | J. Agric. Food Chem. | pmid:22324429 |
| Sakai T et al. | Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. | 2012 | J. Orthop. Res. | pmid:22213202 |
| An J et al. | Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway. | 2012 | Biotechnol. Lett. | pmid:22729748 |
| Kachadourian R et al. | A synthetic chalcone as a potent inducer of glutathione biosynthesis. | 2012 | J. Med. Chem. | pmid:22239485 |