Flavokawain b is a lipid of Polyketides (PK) class. Flavokawain b is associated with abnormalities such as Helminthiasis. The involved functions are known as Cell Death and MAPK Signaling Pathway. Flavokawain b often locates in Blood, Entire bony skeleton and Integumentary system.
To understand associated biological information of Flavokawain b, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Flavokawain b is suspected in Helminthiasis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Flavokawain b
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| He Q et al. | Adenosine 5'-monophosphate-activated protein kinase-dependent mTOR pathway is involved in flavokawain B-induced autophagy in thyroid cancer cells. | 2018 | Cancer Sci. | pmid:29908094 |
| Lee JJ et al. | The Combination of Flavokawain B and Daunorubicin Induces Apoptosis in Human Myeloid Leukemic Cells by Modifying NF-κB. | 2018 | Anticancer Res. | pmid:29715098 |
| Abu Bakar A et al. | Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines. | 2018 | Molecules | pmid:29518053 |
| Rossette MC et al. | The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B. | 2017 | Phytother Res | pmid:28816367 |
| Thieury C et al. | Mechanisms of action and structure-activity relationships of cytotoxic flavokawain derivatives. | 2017 | Bioorg. Med. Chem. | pmid:28214231 |
| Malami I et al. | Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells. | 2017 | PLoS ONE | pmid:28103302 |
| Chang CT et al. | Chalcone flavokawain B induces autophagic-cell death via reactive oxygen species-mediated signaling pathways in human gastric carcinoma and suppresses tumor growth in nude mice. | 2017 | Arch. Toxicol. | pmid:28374157 |
| Yeap SK et al. | Gene Expression Analysis Reveals the Concurrent Activation of Proapoptotic and Antioxidant-Defensive Mechanisms in Flavokawain B-Treated Cervical Cancer HeLa Cells. | 2017 | Integr Cancer Ther | pmid:27458249 |
| Rodrigues DF et al. | Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd. | 2017 | Planta Med. | pmid:27442262 |
| Malami I et al. | In Silico Discovery of Potential Uridine-Cytidine Kinase 2 Inhibitors from the Rhizome of Alpinia mutica. | 2016 | Molecules | pmid:27070566 |
| Abu N et al. | Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro. | 2016 | BMC Complement Altern Med | pmid:26922065 |
| Pinner KD et al. | Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes. | 2016 | Pharm Biol | pmid:26789234 |
| Liu H et al. | Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives. | 2016 | J Enzyme Inhib Med Chem | pmid:26186269 |
| Abu N et al. | In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice. | 2015 | Drug Des Devel Ther | pmid:25834398 |
| Zenger K et al. | Biotransformation of Flavokawains A, B, and C, Chalcones from Kava (Piper methysticum), by Human Liver Microsomes. | 2015 | J. Agric. Food Chem. | pmid:26123050 |
| Tang YL et al. | Flavokawain B inhibits the growth of acute lymphoblastic leukemia cells via p53 and caspase-dependent mechanisms. | 2015 | Leuk. Lymphoma | pmid:25641429 |
| Jeong HJ et al. | Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs. | 2015 | Bioorg. Med. Chem. Lett. | pmid:25597012 |
| Zhang T et al. | The chalcones cardamonin and flavokawain B inhibit the differentiation of preadipocytes to adipocytes by activating ERK. | 2014 | Arch. Biochem. Biophys. | pmid:24845100 |
| Narayanapillai SC et al. | Flavokawains a and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice. | 2014 | Chem. Res. Toxicol. | pmid:25185080 |
| Zhang T et al. | Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells. | 2014 | Food Funct | pmid:24722377 |
| Liu HR et al. | Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B. | 2014 | Bioorg. Med. Chem. Lett. | pmid:25205193 |
| Lebot V et al. | Detection of flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC). | 2014 | Food Chem | pmid:24423570 |
| Ji T et al. | Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis. | 2013 | Mol. Cancer | pmid:23764122 |
| Kamaldin MN et al. | Peripheral antinociception of a chalcone, flavokawin B and possible involvement of the nitric oxide/cyclic guanosine monophosphate/potassium channels pathway. | 2013 | Molecules | pmid:23612473 |
| Lin E et al. | Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo. | 2012 | J. Nutr. Biochem. | pmid:21543203 |
| Feroz SR et al. | Multispectroscopic and molecular modeling approach to investigate the interaction of flavokawain B with human serum albumin. | 2012 | J. Agric. Food Chem. | pmid:22624666 |
| Hseu YC et al. | The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. | 2012 | J. Agric. Food Chem. | pmid:22324429 |
| Sakai T et al. | Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. | 2012 | J. Orthop. Res. | pmid:22213202 |
| An J et al. | Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway. | 2012 | Biotechnol. Lett. | pmid:22729748 |
| Kachadourian R et al. | A synthetic chalcone as a potent inducer of glutathione biosynthesis. | 2012 | J. Med. Chem. | pmid:22239485 |
| Eskander RN et al. | Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. | 2012 | J. Obstet. Gynaecol. Res. | pmid:22540374 |
| Teschke R et al. | Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. | 2011 | Dig Liver Dis | pmid:21377431 |
| Mohamad AS et al. | Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K(+) channels pathway in the systemic antinociception of flavokawin B. | 2011 | Basic Clin. Pharmacol. Toxicol. | pmid:21214864 |
| Zhao X et al. | Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression. | 2011 | Can. J. Physiol. Pharmacol. | pmid:22115332 |
| Zhou P et al. | Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. | 2010 | FASEB J. | pmid:20696856 |
| Mohamad AS et al. | Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice. | 2010 | Eur. J. Pharmacol. | pmid:20826146 |
| Kuo YF et al. | Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. | 2010 | Free Radic. Biol. Med. | pmid:20398749 |
| Tang Y et al. | Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. | 2010 | Int. J. Cancer | pmid:20112340 |
| Burns AR et al. | A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans. | 2010 | Nat. Chem. Biol. | pmid:20512140 |
| Shaik AA et al. | Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19716299 |
| Lin CT et al. | Anti-inflammatory activity of Flavokawain B from Alpinia pricei Hayata. | 2009 | J. Agric. Food Chem. | pmid:19537711 |
| Jhoo JW et al. | In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum). | 2006 | J. Agric. Food Chem. | pmid:16608246 |
| Zi X and Simoneau AR | Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. | 2005 | Cancer Res. | pmid:15833884 |
| Meissner O and Häberlein H | HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16139576 |
| Wu D et al. | Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme. | 2002 | J. Agric. Food Chem. | pmid:11829631 |
| Gu JQ et al. | Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase. | 2002 | J. Nat. Prod. | pmid:12444686 |
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