Flavokawain b is a lipid of Polyketides (PK) class. Flavokawain b is associated with abnormalities such as Helminthiasis. The involved functions are known as Cell Death and MAPK Signaling Pathway. Flavokawain b often locates in Blood, Entire bony skeleton and Integumentary system.
To understand associated biological information of Flavokawain b, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Flavokawain b is suspected in Helminthiasis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Flavokawain b
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Burns AR et al. | A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans. | 2010 | Nat. Chem. Biol. | pmid:20512140 |
| Zhou P et al. | Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. | 2010 | FASEB J. | pmid:20696856 |
| Mohamad AS et al. | Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice. | 2010 | Eur. J. Pharmacol. | pmid:20826146 |
| Mohamad AS et al. | Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K(+) channels pathway in the systemic antinociception of flavokawin B. | 2011 | Basic Clin. Pharmacol. Toxicol. | pmid:21214864 |
| Teschke R et al. | Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. | 2011 | Dig Liver Dis | pmid:21377431 |
| Lin E et al. | Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo. | 2012 | J. Nutr. Biochem. | pmid:21543203 |
| Zhao X et al. | Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression. | 2011 | Can. J. Physiol. Pharmacol. | pmid:22115332 |
| Sakai T et al. | Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. | 2012 | J. Orthop. Res. | pmid:22213202 |
| Kachadourian R et al. | A synthetic chalcone as a potent inducer of glutathione biosynthesis. | 2012 | J. Med. Chem. | pmid:22239485 |
| Hseu YC et al. | The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. | 2012 | J. Agric. Food Chem. | pmid:22324429 |