Flavokawain b is a lipid of Polyketides (PK) class. Flavokawain b is associated with abnormalities such as Helminthiasis. The involved functions are known as Cell Death and MAPK Signaling Pathway. Flavokawain b often locates in Blood, Entire bony skeleton and Integumentary system.
To understand associated biological information of Flavokawain b, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Flavokawain b is suspected in Helminthiasis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Flavokawain b
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jeong HJ et al. | Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs. | 2015 | Bioorg. Med. Chem. Lett. | pmid:25597012 |
| Tang YL et al. | Flavokawain B inhibits the growth of acute lymphoblastic leukemia cells via p53 and caspase-dependent mechanisms. | 2015 | Leuk. Lymphoma | pmid:25641429 |
| Abu N et al. | In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice. | 2015 | Drug Des Devel Ther | pmid:25834398 |
| Zenger K et al. | Biotransformation of Flavokawains A, B, and C, Chalcones from Kava (Piper methysticum), by Human Liver Microsomes. | 2015 | J. Agric. Food Chem. | pmid:26123050 |
| Liu H et al. | Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives. | 2016 | J Enzyme Inhib Med Chem | pmid:26186269 |
| Pinner KD et al. | Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes. | 2016 | Pharm Biol | pmid:26789234 |
| Abu N et al. | Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro. | 2016 | BMC Complement Altern Med | pmid:26922065 |
| Malami I et al. | In Silico Discovery of Potential Uridine-Cytidine Kinase 2 Inhibitors from the Rhizome of Alpinia mutica. | 2016 | Molecules | pmid:27070566 |
| Rodrigues DF et al. | Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd. | 2017 | Planta Med. | pmid:27442262 |
| Yeap SK et al. | Gene Expression Analysis Reveals the Concurrent Activation of Proapoptotic and Antioxidant-Defensive Mechanisms in Flavokawain B-Treated Cervical Cancer HeLa Cells. | 2017 | Integr Cancer Ther | pmid:27458249 |