Flavokawain b is a lipid of Polyketides (PK) class. Flavokawain b is associated with abnormalities such as Helminthiasis. The involved functions are known as Cell Death and MAPK Signaling Pathway. Flavokawain b often locates in Blood, Entire bony skeleton and Integumentary system.
To understand associated biological information of Flavokawain b, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Flavokawain b is suspected in Helminthiasis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Flavokawain b
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Wu D et al. | Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme. | 2002 | J. Agric. Food Chem. | pmid:11829631 |
| Gu JQ et al. | Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase. | 2002 | J. Nat. Prod. | pmid:12444686 |
| Zi X and Simoneau AR | Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. | 2005 | Cancer Res. | pmid:15833884 |
| Meissner O and Häberlein H | HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16139576 |
| Jhoo JW et al. | In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum). | 2006 | J. Agric. Food Chem. | pmid:16608246 |
| Lin CT et al. | Anti-inflammatory activity of Flavokawain B from Alpinia pricei Hayata. | 2009 | J. Agric. Food Chem. | pmid:19537711 |
| Shaik AA et al. | Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19716299 |
| Tang Y et al. | Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. | 2010 | Int. J. Cancer | pmid:20112340 |
| Kuo YF et al. | Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. | 2010 | Free Radic. Biol. Med. | pmid:20398749 |