| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Chlamydia Infections | D002690 | 7 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shoenfelt JL and Fenton MJ | TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent. | 2006 | J. Endotoxin Res. | pmid:16953975 |
| Gäreskog M and Wentzel P | N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. | 2007 | J. Endocrinol. | pmid:17210758 |
| Jimenez SA et al. | Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. | 2001 | J. Clin. Invest. | pmid:11696585 |
| Sumitomo M et al. | Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. | 2002 | J. Clin. Invest. | pmid:11901191 |
| Pabla N et al. | Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. | 2011 | J. Clin. Invest. | pmid:21633170 |
| Frank DE and Carter WG | Laminin 5 deposition regulates keratinocyte polarization and persistent migration. | 2004 | J. Cell. Sci. | pmid:14996912 |
| Hsu HY et al. | Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. | 2008 | J. Cell. Physiol. | pmid:18357586 |
| Hsieh HL et al. | BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes. | 2006 | J. Cell. Physiol. | pmid:15991247 |
| Wu SN et al. | Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells. | 2007 | J. Cell. Physiol. | pmid:17133362 |
| Bankers-Fulbright JL et al. | Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta. | 2001 | J. Cell. Physiol. | pmid:11748588 |
| Gonzalez-Garcia JR et al. | The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs. | 2013 | J. Cell. Physiol. | pmid:22566126 |
| Kudirka JC et al. | P2Y nucleotide receptor signaling through MAPK/ERK is regulated by extracellular matrix: involvement of beta3 integrins. | 2007 | J. Cell. Physiol. | pmid:17620283 |
| Koh YH et al. | Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. | 2011 | J. Cell. Mol. Med. | pmid:20973912 |
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| Löber K et al. | STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816. | 2008 | J. Cell. Biochem. | pmid:17615556 |
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| Hughes PJ et al. | Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. | 2006 | J. Cell. Biochem. | pmid:16178010 |
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| Wen HC and Lin WW | Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells. | 2000 | J. Cell. Biochem. | pmid:10996851 |
| Scott DW and Loo G | Curcumin-induced GADD153 upregulation: modulation by glutathione. | 2007 | J. Cell. Biochem. | pmid:17171638 |
| Alonso E et al. | The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect. | 2008 | J. Cell. Biochem. | pmid:18500723 |
| Brutman-Barazani T et al. | Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes. | 2012 | J. Cell. Biochem. | pmid:22271577 |
| Hsu YC et al. | Ciliogenic RFX transcription factors regulate FGF1 gene promoter. | 2012 | J. Cell. Biochem. | pmid:22415835 |
| Di Rosa M et al. | Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. | 2009 | J. Cell. Biochem. | pmid:19415692 |
| Lin CJ et al. | Rottlerin inhibits migration of follicular thyroid carcinoma cells by PKCdelta-independent destabilization of the focal adhesion complex. | 2010 | J. Cell. Biochem. | pmid:20225271 |
| Di Baldassarre A et al. | Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching. | 2007 | J. Cell. Biochem. | pmid:17212360 |
| Xing AP et al. | Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling. | 2012 | J. Biomed. Biotechnol. | pmid:22754279 |
| Maioli E et al. | Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells. | 2009 | J. Biomed. Biotechnol. | pmid:20168983 |
| Wakino S et al. | Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells. | 2001 | J. Biol. Chem. | pmid:11598137 |
| Soltoff SP | Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation. | 2001 | J. Biol. Chem. | pmid:11498535 |
| Tan M et al. | Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. | 2003 | J. Biol. Chem. | pmid:12431976 |
| Kim HJ et al. | The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. | 2003 | J. Biol. Chem. | pmid:12403780 |
| Wang Q et al. | Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. | 2003 | J. Biol. Chem. | pmid:14527959 |
| Zhao KW et al. | Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. | 2005 | J. Biol. Chem. | pmid:16260419 |
| Hock MB and Brown MA | Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness. | 2003 | J. Biol. Chem. | pmid:12738787 |
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| Ham YM et al. | The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. | 2003 | J. Biol. Chem. | pmid:14514687 |
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| Blois JT et al. | B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta. | 2004 | J. Biol. Chem. | pmid:15138267 |
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| Kajimoto T et al. | Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex. | 2004 | J. Biol. Chem. | pmid:14715667 |
| Chung YW et al. | Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. | 2011 | J. Biol. Chem. | pmid:21705328 |
| López-Huertas MR et al. | Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes. | 2011 | J. Biol. Chem. | pmid:21669868 |
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| Lanaspa MA et al. | The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. | 2010 | J. Biol. Chem. | pmid:20639513 |
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| Reyland ME et al. | Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells. | 1999 | J. Biol. Chem. | pmid:10383415 |