rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
MERRF Syndrome D017243 1 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Translocation, Genetic D014178 20 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Psoriasis D011565 47 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with rottlerin

Download all related citations
Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Huwiler A et al. Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. 2003 Biochem. Biophys. Res. Commun. pmid:12732207
Nishizawa S et al. Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. 2003 Mar-Apr J. Vasc. Res. pmid:12808353
Cummings R et al. Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. 2004 J. Biol. Chem. pmid:15280372
Anantharam V et al. Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. 2004 Ann. N. Y. Acad. Sci. pmid:15681813
Huda R et al. Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle. 2004 Shock pmid:15167677
Bazuine M et al. Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes. 2004 Biochem. Pharmacol. pmid:15183122
Deszo EL et al. IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta. 2004 Cell. Signal. pmid:14636897
Woo CH et al. Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. 2004 J. Immunol. pmid:15557194
Kang HS et al. Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. 2004 Mol. Cells pmid:15232218
Cho CH et al. Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:14704231