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Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. |
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Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. |
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2004 |
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A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. |
2004 |
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Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. |
2004 |
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Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. |
2004 |
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Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. |
2004 |
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Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction. |
2004 |
J. Pharmacol. Exp. Ther. |
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Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. |
2004 |
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Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway. |
2004 |
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Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. |
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J. Immunol. |
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Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. |
2004 |
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Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. |
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Am. J. Physiol. Heart Circ. Physiol. |
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Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. |
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Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells. |
2003 |
Am. J. Physiol., Cell Physiol. |
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Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. |
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The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. |
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Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. |
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Neuroscience |
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Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). |
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Asbestos-induced apoptosis is protein kinase C delta-dependent. |
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Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. |
2003 |
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. |
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Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones. |
2003 |
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Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. |
2003 |
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A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. |
2003 |
Neuroscience |
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Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function. |
2003 |
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Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. |
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Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. |
2003 |
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Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness. |
2003 |
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Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. |
2003 |
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Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. |
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Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. |
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Effect of detergent on "promiscuous" inhibitors. |
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Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. |
2003 |
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Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils. |
2003 |
Arch. Biochem. Biophys. |
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Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. |
2003 |
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Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity. |
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Am. J. Physiol. Gastrointest. Liver Physiol. |
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The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. |
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Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression. |
2003 |
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Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism. |
2003 |
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A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion. |
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Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. |
2003 |
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