Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Kim H et al. | EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells. | 2011 | J. Immunother. | pmid:21499124 |
Valacchi G et al. | Rottlerin exhibits antiangiogenic effects in vitro. | 2011 | Chem Biol Drug Des | pmid:21435184 |
Uruno A et al. | All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. | 2011 | J. Leukoc. Biol. | pmid:21393419 |
Ku CS et al. | Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells. | 2011 | Nutr Res | pmid:21530801 |
Kim YR et al. | Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation. | 2011 | Cell Biochem. Biophys. | pmid:21468691 |
Leverence JT et al. | Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation. | 2011 | Chem. Biol. Interact. | pmid:20920494 |
Park EJ and Kwon TK | Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. | 2011 | Exp. Mol. Med. | pmid:21971413 |
Chen Z et al. | Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors. | 2011 | Endocr. Relat. Cancer | pmid:21990324 |
Clements RT et al. | Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts. | 2011 | Circulation | pmid:21911819 |
Sarkar N et al. | Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. | 2011 | Biochim. Biophys. Acta | pmid:21723915 |