Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Thomas R and Kim MH | Targeting the hypoxia inducible factor pathway with mitochondrial uncouplers. | 2007 | Mol. Cell. Biochem. | pmid:16924414 |
Park YS et al. | Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17363696 |
Bull ND et al. | Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. | 2007 | Curr. Eye Res. | pmid:17364745 |
Kamiya K et al. | Protein kinase C delta activated adhesion regulates vascular smooth muscle cell migration. | 2007 | J. Surg. Res. | pmid:17574042 |
Nakatake M et al. | STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells. | 2007 | Cell Cycle | pmid:17525530 |
Pugazhenthi S et al. | Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17535857 |
Zhu S et al. | Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle. | 2006 Mar-Apr | Lung | pmid:16622778 |
Fan Y et al. | [Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:17313780 |
Hsu PC et al. | Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2. | 2006 | Apoptosis | pmid:16520895 |
Suguro T et al. | Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. | 2006 | Atherosclerosis | pmid:16157345 |
Fronhofer V et al. | Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages. | 2006 | J. Leukoc. Biol. | pmid:16330529 |
Nakajima T et al. | Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines. | 2006 | Mutat. Res. | pmid:16337250 |
Hanrott K et al. | 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. | 2006 | J. Biol. Chem. | pmid:16361258 |
Tapia JA et al. | Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism. | 2006 | Biochim. Biophys. Acta | pmid:16364465 |
Collins NT et al. | Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16269664 |
Andreeva AY et al. | Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16257565 |
Hughes PJ et al. | Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. | 2006 | J. Cell. Biochem. | pmid:16178010 |
Hsieh HL et al. | BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes. | 2006 | J. Cell. Physiol. | pmid:15991247 |
Jane EP et al. | Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16959960 |
Zeng H et al. | Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16928897 |
Pula G et al. | PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. | 2006 | Blood | pmid:16940418 |
Shukla A et al. | Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. | 2006 | FASEB J. | pmid:16571779 |
Rushworth SA et al. | Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16460683 |
Ringshausen I et al. | Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL. | 2006 | Leukemia | pmid:16437144 |
Zatta AJ et al. | Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling. | 2006 | Cardiovasc. Res. | pmid:16443207 |
Zhu M et al. | Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes. | 2006 | Cancer Lett. | pmid:16455194 |
Ikewaki N et al. | Regulation of CD93 cell surface expression by protein kinase C isoenzymes. | 2006 | Microbiol. Immunol. | pmid:16490927 |
SedmÃková M et al. | Effect of protein kinase C inhibitors on porcine oocyte activation. | 2006 | J. Exp. Zoolog. Part A Comp. Exp. Biol. | pmid:16493646 |
Waki K et al. | Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils. | 2006 | Free Radic. Res. | pmid:16517500 |
Takahashi A et al. | Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. | 2006 | Nat. Cell Biol. | pmid:17028578 |
Pakozdi A et al. | Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. | 2006 | Arthritis Res. Ther. | pmid:16872482 |
Zhou Y et al. | Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16950644 |
Sarkis PT et al. | STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha. | 2006 | J. Immunol. | pmid:16982890 |
Shoichet BK | Interpreting steep dose-response curves in early inhibitor discovery. | 2006 | J. Med. Chem. | pmid:17149857 |
Cronshaw DG et al. | Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22. | 2006 | J. Leukoc. Biol. | pmid:16614259 |
Lee CF et al. | Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress. | 2006 | Free Radic. Biol. Med. | pmid:16785027 |
Zou Y et al. | Contact inhibition causes strong downregulation of expression of MICA in human fibroblasts and decreased NK cell killing. | 2006 | Hum. Immunol. | pmid:16698440 |
Nobe K et al. | High-glucose-altered endothelial cell function involves both disruption of cell-to-cell connection and enhancement of force development. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16699065 |
Im YJ et al. | Multiple actions of lysophosphatidylcholine in human Jurkat T cells. | 2006 | Acta Pharmacol. Sin. | pmid:16723088 |
Ahn BK et al. | Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium. | 2006 | J. Invest. Dermatol. | pmid:16575394 |
Chen ZF et al. | [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. | 2006 | Zhonghua Zhong Liu Za Zhi | pmid:17236547 |
Ceni E et al. | Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells. | 2006 | Gastroenterology | pmid:17030193 |
Shoenfelt JL and Fenton MJ | TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent. | 2006 | J. Endotoxin Res. | pmid:16953975 |
Wung BS et al. | Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. | 2006 | Pharmacol. Res. | pmid:16243536 |
Jang IS et al. | Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process. | 2006 | Mech. Ageing Dev. | pmid:16516270 |
Barman SA and Marrero MB | Mechanism of endothelin-1 activation of MAP kinases in neonatal pulmonary vascular smooth muscle. | 2005 Nov-Dec | Lung | pmid:16465602 |
Obara K et al. | Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model. | 2005 Jan-Feb | J. Vasc. Res. | pmid:15637442 |
Nabha SM et al. | Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. | 2005 | Oncogene | pmid:15735693 |
Nitti M et al. | Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons. | 2005 | Free Radic. Biol. Med. | pmid:15749380 |
Hurbin A et al. | Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. | 2005 | J. Biol. Chem. | pmid:15767261 |
Obreja O et al. | Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. | 2005 | Brain | pmid:15817518 |
Wiedłocha A et al. | Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1. | 2005 | Mol. Biol. Cell | pmid:15574884 |
Amos S et al. | Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. | 2005 | J. Biol. Chem. | pmid:15618223 |
Sarkar K et al. | Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells. | 2005 | Immunology | pmid:16313365 |
Zhang X et al. | NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. | 2005 | EMBO J. | pmid:16319926 |
Payvandi F et al. | Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT. | 2005 | J. Interferon Cytokine Res. | pmid:16241859 |
Kim IS et al. | Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells. | 2005 | FEBS Lett. | pmid:16226254 |
Zhao KW et al. | Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. | 2005 | J. Biol. Chem. | pmid:16260419 |
Oh JI et al. | Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. | 2005 | Cancer Lett. | pmid:16297709 |
Woo CH et al. | VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15489375 |
Lewis AE et al. | Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. | 2005 | Cell. Signal. | pmid:15494216 |
Zhang J et al. | PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. | 2005 | J. Cell. Biochem. | pmid:16114000 |
Brown JM et al. | Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16040631 |
Kishida O et al. | Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15723263 |
Rao PE et al. | Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}. | 2005 | J. Immunol. | pmid:15661903 |
Ducroc R et al. | Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. | 2005 | Diabetes | pmid:15677491 |
Ahmed S et al. | Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line. | 2005 | FEBS J. | pmid:15691325 |
Fan CY et al. | PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy. | 2005 | Biochem. J. | pmid:15913451 |
Panaretakis T et al. | Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. | 2005 | Mol. Biol. Cell | pmid:15917298 |
Tse SM et al. | Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. | 2005 | J. Biol. Chem. | pmid:15863503 |
Miguel BG et al. | Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells. | 2005 | Biochim. Biophys. Acta | pmid:15843035 |
Liao YF et al. | The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade. | 2005 | Life Sci. | pmid:15922001 |
Roose JP et al. | A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. | 2005 | Mol. Cell. Biol. | pmid:15899849 |
Zakharov SI et al. | Activation of the BK (SLO1) potassium channel by mallotoxin. | 2005 | J. Biol. Chem. | pmid:15998639 |
Avila GE et al. | Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15976015 |
Chen S et al. | Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15955695 |
Tepperman BL et al. | Effect of protein kinase C activation on intracellular Ca2+ signaling and integrity of intestinal epithelial cells. | 2005 | Eur. J. Pharmacol. | pmid:16005455 |
Yamaguchi K et al. | Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. | 2005 | Cancer Chemother. Pharmacol. | pmid:16012865 |
Skaletz-Rorowski A et al. | PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. | 2005 | Cardiovasc. Res. | pmid:15949478 |
Kim DC et al. | Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16182255 |
Styles NA et al. | Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C. | 2005 | Neurochem. Int. | pmid:16183168 |
Kim EH et al. | Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. | 2005 | Oncogene | pmid:15531913 |
Cummings R et al. | Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. | 2004 | J. Biol. Chem. | pmid:15280372 |
Kohro S et al. | Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. | 2004 | Anesth. Analg. | pmid:15502023 |
Bey EA et al. | Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. | 2004 | J. Immunol. | pmid:15494525 |
Tan M et al. | Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15499041 |
Welters HJ et al. | Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. | 2004 | J. Mol. Endocrinol. | pmid:14766004 |
Anantharam V et al. | Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15681813 |
Deszo EL et al. | IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta. | 2004 | Cell. Signal. | pmid:14636897 |
Ryazanova LV et al. | Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. | 2004 | J. Biol. Chem. | pmid:14594813 |
Durrant D et al. | The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358112 |
You HJ et al. | A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358156 |
Deutsch E et al. | Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. | 2004 | J. Virol. | pmid:15331751 |
Wheaton K and Riabowol K | Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. | 2004 | Mol. Cell. Biol. | pmid:15282327 |
Schreckenberg R et al. | Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. | 2004 | Cardiovasc. Res. | pmid:15276481 |
Chintalgattu V and Katwa LC | Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15240825 |
Li C et al. | Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15217780 |
Shin SY et al. | Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. | 2004 | J. Mol. Biol. | pmid:15223313 |
Kang HS et al. | Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. | 2004 | Mol. Cells | pmid:15232218 |
Lladó A et al. | Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. | 2004 | Mol. Biol. Cell | pmid:15342779 |