rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tang CH et al. | The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts. | 2010 | Arthritis Rheum. | pmid:20862675 |
| Xie MJ et al. | Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ. | 2010 | Clin. Exp. Pharmacol. Physiol. | pmid:20880184 |
| Ohno I et al. | Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19762431 |
| Hwang YP et al. | 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression. | 2010 | Toxicol. Lett. | pmid:20599481 |
| Lanaspa MA et al. | The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. | 2010 | J. Biol. Chem. | pmid:20639513 |
| Maioli E and Valacchi G | Rottlerin: bases for a possible usage in psoriasis. | 2010 | Curr. Drug Metab. | pmid:20540694 |
| Arisaka M et al. | Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells. | 2010 | FEBS Lett. | pmid:20122929 |
| Wallerstedt E et al. | Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells. | 2010 | Diabetologia | pmid:20151299 |
| Liu J et al. | The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells. | 2010 | J Tissue Eng Regen Med | pmid:20033927 |
| Shumilina E et al. | Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. | 2010 | Cell. Physiol. Biochem. | pmid:21063107 |
| Suzuki T and Hara H | Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. | 2009 | J. Nutr. | pmid:19297429 |
| Fordjour AK and Harrington EO | PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function. | 2009 | Biochim. Biophys. Acta | pmid:19632305 |
| Fan Y et al. | Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation. | 2009 | Neurosci Bull | pmid:19633700 |
| Esper RM and Loeb JA | Neurotrophins induce neuregulin release through protein kinase Cdelta activation. | 2009 | J. Biol. Chem. | pmid:19648576 |
| Zhao M et al. | Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells. | 2009 | PLoS ONE | pmid:19662097 |
| Park SK et al. | Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. | 2009 | Carcinogenesis | pmid:19420016 |
| Matsuoka H et al. | Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways. | 2009 | Exp. Cell Res. | pmid:19393235 |
| Di Rosa M et al. | Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. | 2009 | J. Cell. Biochem. | pmid:19415692 |
| Sugiya H et al. | Role of protein kinase C-delta in isoproterenol-induced amylase release in rat parotid acinar cells. | 2009 | J. Med. Invest. | pmid:20224227 |
| Kato K et al. | Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells. | 2009 | Am. J. Physiol. Heart Circ. Physiol. | pmid:19837952 |