Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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McNally AK et al. | Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. | 2008 | Exp. Mol. Pathol. | pmid:18067888 |
Shukla A et al. | Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. | 2006 | FASEB J. | pmid:16571779 |
Goldklang MP et al. | Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. | 2013 | FASEB J. | pmid:23995289 |
Ahmed S et al. | Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line. | 2005 | FEBS J. | pmid:15691325 |
Kim IS et al. | Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells. | 2005 | FEBS Lett. | pmid:16226254 |
Meacci E et al. | Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. | 2000 | FEBS Lett. | pmid:11018530 |
Arisaka M et al. | Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells. | 2010 | FEBS Lett. | pmid:20122929 |
Gschwendt M et al. | Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. | 1994 | FEBS Lett. | pmid:8307162 |
Keenan C et al. | Isoform specificity of activators and inhibitors of protein kinase C gamma and delta. | 1997 | FEBS Lett. | pmid:9326378 |
Chen RC et al. | Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. | 2015 | Food Funct | pmid:25773745 |
Marengo B et al. | Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma. | 2008 | Free Radic. Biol. Med. | pmid:17991446 |
Nitti M et al. | Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons. | 2005 | Free Radic. Biol. Med. | pmid:15749380 |
Domenicotti C et al. | Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. | 2003 | Free Radic. Biol. Med. | pmid:12927600 |
Lee CF et al. | Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress. | 2006 | Free Radic. Biol. Med. | pmid:16785027 |
Prast-Nielsen S et al. | Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay. | 2011 | Free Radic. Biol. Med. | pmid:21262347 |
Niwa K et al. | Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells. | 2002 | Free Radic. Res. | pmid:12592666 |
Waki K et al. | Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils. | 2006 | Free Radic. Res. | pmid:16517500 |
Ceni E et al. | Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells. | 2006 | Gastroenterology | pmid:17030193 |
Kitamura K et al. | The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression. | 2003 | Genes Cells | pmid:12653960 |
Lesage GD et al. | Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity. | 2002 | Hepatology | pmid:12198656 |