rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Balgi AD et al. | Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. | 2009 | PLoS ONE | pmid:19771169 |
| Löber K et al. | STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816. | 2008 | J. Cell. Biochem. | pmid:17615556 |
| Wang Y et al. | Differential effects of dialysis and ultrafiltrate from individuals with CKD, with or without diabetes, on platelet phosphatidylserine externalization. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:17670899 |
| Leonarduzzi G et al. | Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture. | 2008 | Aging Cell | pmid:18331615 |
| Kim S et al. | Role of protein kinase Cdelta in paraquat-induced glial cell death. | 2008 | J. Neurosci. Res. | pmid:18335519 |
| Park S et al. | Chlorpromazine attenuates pancreatic beta-cell function and mass through IRS2 degradation, while exercise partially reverses the attenuation. | 2008 | J. Psychopharmacol. (Oxford) | pmid:18308779 |
| Fang Q et al. | PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18342628 |
| Liu N et al. | Erbin-regulated sensitivity of MCF-7 breast cancer cells to TRAIL via ErbB2/AKT/NF-kappaB pathway. | 2008 | J. Biochem. | pmid:18316330 |
| Goon Goh F et al. | G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes. | 2008 | Cell. Signal. | pmid:18424071 |
| Song KS et al. | Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis. | 2008 | Autophagy | pmid:18424913 |
| Basu A et al. | Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway. | 2008 | Cancer Res. | pmid:18413747 |
| Schonhoff CM et al. | Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. | 2008 | Hepatology | pmid:18273864 |
| Hsu HY et al. | Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. | 2008 | J. Cell. Physiol. | pmid:18357586 |
| Feng BY et al. | Small-molecule aggregates inhibit amyloid polymerization. | 2008 | Nat. Chem. Biol. | pmid:18223646 |
| Lee MC et al. | Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages. | 2008 | J. Leukoc. Biol. | pmid:18511573 |
| Ross R et al. | Hypothalamic protein kinase C regulates glucose production. | 2008 | Diabetes | pmid:18511848 |
| Sakai H et al. | Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine. | 2008 | J Smooth Muscle Res | pmid:18480594 |
| Alonso E et al. | The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect. | 2008 | J. Cell. Biochem. | pmid:18500723 |
| Kim YH et al. | Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway. | 2008 | Diabetes | pmid:18443201 |
| Byun HS et al. | Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase. | 2008 | Exp. Mol. Med. | pmid:18446057 |