Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Kang JH et al. | Plasma protein kinase C (PKC)alpha as a biomarker for the diagnosis of cancers. | 2009 | Carcinogenesis | pmid:19710177 |
Lim JH et al. | Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells. | 2009 | Carcinogenesis | pmid:19037087 |
Szilagyi K et al. | PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages. | 2014 | Cardiovasc. Res. | pmid:25253077 |
Skaletz-Rorowski A et al. | PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. | 2005 | Cardiovasc. Res. | pmid:15949478 |
Zatta AJ et al. | Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling. | 2006 | Cardiovasc. Res. | pmid:16443207 |
Schreckenberg R et al. | Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. | 2004 | Cardiovasc. Res. | pmid:15276481 |
Kim YR et al. | Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation. | 2011 | Cell Biochem. Biophys. | pmid:21468691 |
Nakatake M et al. | STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells. | 2007 | Cell Cycle | pmid:17525530 |
Basu A et al. | Involvement of protein kinase C-delta in DNA damage-induced apoptosis. | 2001 | Cell Death Differ. | pmid:11526445 |
Hasima N and Ozpolat B | Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. | 2014 | Cell Death Dis | pmid:25375374 |