Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Obara K et al. | Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model. | 2005 Jan-Feb | J. Vasc. Res. | pmid:15637442 |
Barman SA and Marrero MB | Mechanism of endothelin-1 activation of MAP kinases in neonatal pulmonary vascular smooth muscle. | 2005 Nov-Dec | Lung | pmid:16465602 |
Hsu PC et al. | Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2. | 2006 | Apoptosis | pmid:16520895 |
Fronhofer V et al. | Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages. | 2006 | J. Leukoc. Biol. | pmid:16330529 |
Nakajima T et al. | Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines. | 2006 | Mutat. Res. | pmid:16337250 |
Hanrott K et al. | 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. | 2006 | J. Biol. Chem. | pmid:16361258 |
Tapia JA et al. | Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism. | 2006 | Biochim. Biophys. Acta | pmid:16364465 |
Collins NT et al. | Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16269664 |
Hsieh HL et al. | BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes. | 2006 | J. Cell. Physiol. | pmid:15991247 |
Waki K et al. | Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils. | 2006 | Free Radic. Res. | pmid:16517500 |
Takahashi A et al. | Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. | 2006 | Nat. Cell Biol. | pmid:17028578 |
Pakozdi A et al. | Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. | 2006 | Arthritis Res. Ther. | pmid:16872482 |
Zhou Y et al. | Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16950644 |
Sarkis PT et al. | STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha. | 2006 | J. Immunol. | pmid:16982890 |
Shoichet BK | Interpreting steep dose-response curves in early inhibitor discovery. | 2006 | J. Med. Chem. | pmid:17149857 |
Cronshaw DG et al. | Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22. | 2006 | J. Leukoc. Biol. | pmid:16614259 |
Lee CF et al. | Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress. | 2006 | Free Radic. Biol. Med. | pmid:16785027 |
Zou Y et al. | Contact inhibition causes strong downregulation of expression of MICA in human fibroblasts and decreased NK cell killing. | 2006 | Hum. Immunol. | pmid:16698440 |
Ceni E et al. | Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells. | 2006 | Gastroenterology | pmid:17030193 |
Jang IS et al. | Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process. | 2006 | Mech. Ageing Dev. | pmid:16516270 |