Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fan Y et al. | [Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:17313780 |
Suguro T et al. | Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. | 2006 | Atherosclerosis | pmid:16157345 |
Collins NT et al. | Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16269664 |
Andreeva AY et al. | Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16257565 |
Hughes PJ et al. | Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. | 2006 | J. Cell. Biochem. | pmid:16178010 |
Jane EP et al. | Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16959960 |
Zeng H et al. | Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16928897 |
Pula G et al. | PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. | 2006 | Blood | pmid:16940418 |
Shukla A et al. | Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. | 2006 | FASEB J. | pmid:16571779 |
Rushworth SA et al. | Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16460683 |
Ringshausen I et al. | Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL. | 2006 | Leukemia | pmid:16437144 |
Zatta AJ et al. | Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling. | 2006 | Cardiovasc. Res. | pmid:16443207 |
Zhu M et al. | Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes. | 2006 | Cancer Lett. | pmid:16455194 |
Nobe K et al. | High-glucose-altered endothelial cell function involves both disruption of cell-to-cell connection and enhancement of force development. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16699065 |
Im YJ et al. | Multiple actions of lysophosphatidylcholine in human Jurkat T cells. | 2006 | Acta Pharmacol. Sin. | pmid:16723088 |
Ahn BK et al. | Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium. | 2006 | J. Invest. Dermatol. | pmid:16575394 |
Chen ZF et al. | [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. | 2006 | Zhonghua Zhong Liu Za Zhi | pmid:17236547 |
Shoenfelt JL and Fenton MJ | TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent. | 2006 | J. Endotoxin Res. | pmid:16953975 |
Wung BS et al. | Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. | 2006 | Pharmacol. Res. | pmid:16243536 |
Jang IS et al. | Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process. | 2006 | Mech. Ageing Dev. | pmid:16516270 |