Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Leitges M et al. | Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells. | 2001 | Lab. Invest. | pmid:11502860 |
Jackson TA et al. | Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCdelta. | 2001 | Mol. Endocrinol. | pmid:11518800 |
Basu A et al. | Involvement of protein kinase C-delta in DNA damage-induced apoptosis. | 2001 | Cell Death Differ. | pmid:11526445 |
Heit I et al. | Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblasts. | 2001 | Oncogene | pmid:11526503 |
Grandvaux N et al. | Oxidant-dependent phosphorylation of p40phox in B lymphocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573965 |
Shanmugam M et al. | A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction. | 2001 | Cancer Lett. | pmid:11595128 |
Wakino S et al. | Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells. | 2001 | J. Biol. Chem. | pmid:11598137 |
Wang GY et al. | Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11602672 |
Jimenez SA et al. | Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. | 2001 | J. Clin. Invest. | pmid:11696585 |
Wang Y et al. | Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. | 2001 | J. Mol. Cell. Cardiol. | pmid:11708847 |
Blass M et al. | Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. | 2002 | Mol. Cell. Biol. | pmid:11739733 |
Han JM et al. | Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. | 2002 | J. Biol. Chem. | pmid:11744693 |
Bankers-Fulbright JL et al. | Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta. | 2001 | J. Cell. Physiol. | pmid:11748588 |
Chen JH et al. | Rottlerin stimulates metallothionein gene expression but inhibits metal transport in Chinese hamster ovary cells. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11749125 |
Lange Y et al. | Effect of protein kinase C on endoplasmic reticulum cholesterol. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779197 |
Li B et al. | Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. | 2002 | J. Biol. Chem. | pmid:11796722 |
Kucich U et al. | Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:11804868 |
Erclik MS and Mitchell J | The role of protein kinase C-delta in PTH stimulation of IGF-binding protein-5 mRNA in UMR-106-01 cells. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11832354 |
Zhao H et al. | Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:11880333 |
Anantharam V et al. | Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. | 2002 | J. Neurosci. | pmid:11880503 |