rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sumitomo M et al. | Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. | 2002 | J. Clin. Invest. | pmid:11901191 |
| Todt JC et al. | Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages. | 2002 | J. Biol. Chem. | pmid:12114511 |
| Lange Y et al. | Effect of protein kinase C on endoplasmic reticulum cholesterol. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779197 |
| Blass M et al. | Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. | 2002 | Mol. Cell. Biol. | pmid:11739733 |
| Han JM et al. | Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. | 2002 | J. Biol. Chem. | pmid:11744693 |
| Kucich U et al. | Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:11804868 |
| Li B et al. | Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. | 2002 | J. Biol. Chem. | pmid:11796722 |
| Basu A et al. | Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway. | 2002 | Exp. Cell Res. | pmid:12169276 |
| Cruciani V and Mikalsen SO | Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts. | 2002 | Toxicol. Appl. Pharmacol. | pmid:12127264 |
| Kayali AG et al. | Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. | 2002 | Endocrinology | pmid:12239100 |
| Saito S et al. | Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. | 2002 | J. Biol. Chem. | pmid:12226102 |
| Basu A and Miura A | Differential regulation of extrinsic and intrinsic cell death pathways by protein kinase C. | 2002 | Int. J. Mol. Med. | pmid:12373288 |
| Saraiva L et al. | Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta. | 2003 | J Enzyme Inhib Med Chem | pmid:15008511 |
| Blanquet PR et al. | A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. | 2003 | Neuroscience | pmid:12699783 |
| Harrington EO et al. | Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12707019 |
| Wang L et al. | Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. | 2003 | Biochem. J. | pmid:12720544 |
| Huwiler A et al. | Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12732207 |
| Hock MB and Brown MA | Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness. | 2003 | J. Biol. Chem. | pmid:12738787 |
| Maddox JF et al. | Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. | 2003 | Chem. Res. Toxicol. | pmid:12755590 |
| Takizawa T et al. | Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. | 2003 | Int. Arch. Allergy Immunol. | pmid:12771544 |