Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Wang P et al. | Relaxin Inhibits Cardiac Fibrosis in Diabetic Rats: Roles of Protein Kinase Cδ. | 2018 | Exp. Clin. Endocrinol. Diabetes | pmid:28895644 |
Juneja M et al. | Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. | 2017 | PLoS Biol. | pmid:28570591 |
Serrero M et al. | PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production. | 2017 | Sci Rep | pmid:28539656 |
Ietta F et al. | Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells. | 2017 | Sci Rep | pmid:28455500 |
Zhu Y et al. | Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma. | 2017 | Oncotarget | pmid:28423559 |
Misuth M et al. | Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. | 2017 | Photodiagnosis Photodyn Ther | pmid:28373118 |
Guan X et al. | Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. | 2017 | Sci Rep | pmid:28165042 |
Abdelnabi R et al. | Protein kinases C as potential host targets for the inhibition of chikungunya virus replication. | 2017 | Antiviral Res. | pmid:28039020 |
Zhao Z et al. | Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer. | 2017 | Oncotarget | pmid:27999199 |
Matschke V et al. | The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. | 2016 | Cell. Physiol. Biochem. | pmid:27997884 |
Kim MH et al. | EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. | 2017 | Toxicol. Appl. Pharmacol. | pmid:27939242 |
Mischitelli M et al. | Stimulation of Suicidal Erythrocyte Death by Rottlerin. | 2016 | Cell. Physiol. Biochem. | pmid:27889758 |
So KY and Oh SH | Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells. | 2016 | Toxicology | pmid:27658547 |
Wang L et al. | Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. | 2016 | Oncotarget | pmid:27626499 |
Yin X et al. | Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells. | 2016 | Oncotarget | pmid:27582552 |
Pandey S et al. | Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27498028 |
Lishmanov YB et al. | Involvement of Protein Kinase C-δ in the Realization of Cardioprotective Effect of Ischemic Postconditioning. | 2016 | Bull. Exp. Biol. Med. | pmid:27496038 |
Lee NR et al. | Cytokine secreted by S100A9 via TLR4 in monocytes delays neutrophil apoptosis by inhibition of caspase 9/3 pathway. | 2016 | Cytokine | pmid:27459393 |
Xie L et al. | Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. | 2016 | PLoS ONE | pmid:27442243 |
Oyedemi BO et al. | Novel R-plasmid conjugal transfer inhibitory and antibacterial activities of phenolic compounds from Mallotus philippensis (Lam.) Mull. Arg. | 2016 | J Glob Antimicrob Resist | pmid:27436460 |