Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Efimova T and Eckert RL | Regulation of human involucrin promoter activity by novel protein kinase C isoforms. | 2000 | J. Biol. Chem. | pmid:10636851 |
Cross T et al. | PKC-delta is an apoptotic lamin kinase. | 2000 | Oncogene | pmid:10822384 |
Peters CA et al. | Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. | 2000 | Mol. Endocrinol. | pmid:10770494 |
Kilpatrick LE et al. | Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078718 |
Lee SD et al. | Bradykinin activates phospholipase D2 via protein kinase cdelta in PC12 cells. | 2000 | Neurosci. Lett. | pmid:11058804 |
Chen NY et al. | Activation of PKC is required for arsenite-induced signal transduction. | 2000 | J. Environ. Pathol. Toxicol. Oncol. | pmid:10983896 |
Wen HC and Lin WW | Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells. | 2000 | J. Cell. Biochem. | pmid:10996851 |
Meacci E et al. | Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. | 2000 | FEBS Lett. | pmid:11018530 |
Gallagher HC et al. | Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta. | 2000 | J. Neurosci. Res. | pmid:10972960 |
Cho SI et al. | Novel compounds, '1,3-selenazine derivatives' as specific inhibitors of eukaryotic elongation factor-2 kinase. | 2000 | Biochim. Biophys. Acta | pmid:10913818 |
Kontny E et al. | Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. | 2000 | J. Leukoc. Biol. | pmid:10670587 |
Alexander SR et al. | Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils. | 2000 | J. Leukoc. Biol. | pmid:10733103 |
Davies SP et al. | Specificity and mechanism of action of some commonly used protein kinase inhibitors. | 2000 | Biochem. J. | pmid:10998351 |
Fryer RM et al. | Essential activation of PKC-delta in opioid-initiated cardioprotection. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179083 |
De Witt BJ et al. | Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133494 |
Takahashi T and Shibuya M | The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162532 |
Shanmugam M et al. | A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction. | 2001 | Cancer Lett. | pmid:11595128 |
Wakino S et al. | Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells. | 2001 | J. Biol. Chem. | pmid:11598137 |
Wang Y et al. | Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. | 2001 | J. Mol. Cell. Cardiol. | pmid:11708847 |
Bankers-Fulbright JL et al. | Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta. | 2001 | J. Cell. Physiol. | pmid:11748588 |