rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Palmer TM and Stiles GL | Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms. | 1999 | Biochemistry | pmid:10555965 |
| Basu A and Akkaraju GR | Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C. | 1999 | Biochemistry | pmid:10194341 |
| Chao H et al. | Activation of bradykinin B2 receptor induced the inflammatory responses of cytosolic phospholipase A after the early traumatic brain injury. | 2018 | Biochim Biophys Acta Mol Basis Dis | pmid:29894755 |
| Tapia JA et al. | Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism. | 2006 | Biochim. Biophys. Acta | pmid:16364465 |
| Miguel BG et al. | Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells. | 2005 | Biochim. Biophys. Acta | pmid:15843035 |
| Tomkova S et al. | In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells. | 2018 | Biochim. Biophys. Acta | pmid:29410069 |
| Cho SI et al. | Novel compounds, '1,3-selenazine derivatives' as specific inhibitors of eukaryotic elongation factor-2 kinase. | 2000 | Biochim. Biophys. Acta | pmid:10913818 |
| Sugawara T et al. | PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus. | 2012 | Biochim. Biophys. Acta | pmid:22326427 |
| Ahn BH et al. | Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. | 2007 | Biochim. Biophys. Acta | pmid:17640750 |
| Liu CY et al. | Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA. | 2009 | Biochim. Biophys. Acta | pmid:19477272 |
| Fordjour AK and Harrington EO | PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function. | 2009 | Biochim. Biophys. Acta | pmid:19632305 |
| Sarkar N et al. | Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. | 2011 | Biochim. Biophys. Acta | pmid:21723915 |
| Choi YA et al. | Integrin signaling and cell spreading alterations by rottlerin treatment of chick limb bud mesenchymal cells. | 2009 | Biochimie | pmid:19306958 |
| Park EJ et al. | Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells. | 2010 | Biochimie | pmid:19833168 |
| Matta C et al. | PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures. | 2011 | Biochimie | pmid:20850497 |
| Kaur K et al. | Possible mechanism of rottlerin induced modulation of ischemia reperfusion injury in isolated rat hearts. | 2008 | Biol. Pharm. Bull. | pmid:18758070 |
| Budnik LT and Mukhopadhyay AK | Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone. | 2002 | Biol. Reprod. | pmid:12193405 |
| Yang QE et al. | Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. | 2011 | Biol. Reprod. | pmid:21191110 |
| Tuorkey MJ | Cancer Therapy with Phytochemicals: Present and Future Perspectives. | 2015 | Biomed. Environ. Sci. | pmid:26695359 |
| Rohilla A et al. | Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts. | 2010 | Biomed. Pharmacother. | pmid:19914792 |