Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kudo M et al. | Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12063302 |
Miura T et al. | Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17513490 |
De Witt BJ et al. | Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133494 |
Sud N et al. | Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18192589 |
Liedtke CM et al. | Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11943682 |
Woo CH et al. | VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15489375 |
Brown JM et al. | Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16040631 |
Wang Y et al. | Differential effects of dialysis and ultrafiltrate from individuals with CKD, with or without diabetes, on platelet phosphatidylserine externalization. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:17670899 |
Zhao H et al. | Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:11880333 |
Wang Y et al. | Protein kinase C regulates urea permeability in the rat inner medullary collecting duct. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20861079 |
Wang Y et al. | Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17625040 |
Ramnath RD et al. | Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18160487 |
Kilpatrick LE et al. | A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:12055072 |
Liedtke CM et al. | Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells. | 2003 | Am. J. Physiol., Cell Physiol. | pmid:12388079 |
Kilpatrick LE et al. | Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078718 |
Mishra R et al. | TGF-beta-regulated collagen type I accumulation: role of Src-based signals. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135298 |
Hassan HA et al. | Regulation of anion exchanger Slc26a6 by protein kinase C. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17151144 |
Zhang H and Forman HJ | Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18048804 |
Kucich U et al. | Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:11804868 |
Shukla A et al. | Asbestos-induced apoptosis is protein kinase C delta-dependent. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12626342 |