Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Takahashi T and Shibuya M | The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162532 |
Grandvaux N et al. | Oxidant-dependent phosphorylation of p40phox in B lymphocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573965 |
Lange Y et al. | Effect of protein kinase C on endoplasmic reticulum cholesterol. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779197 |
Wang Z et al. | Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29203243 |
Pandey S et al. | Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27498028 |
Leung CH et al. | PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11444839 |
Dietrich C et al. | Rottlerin induces a transformed phenotype in human keratinocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401499 |
Fang Q et al. | PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18342628 |
Liu JF et al. | FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054499 |
Huwiler A et al. | Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12732207 |
Rushworth SA et al. | Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16460683 |
Durrant D et al. | The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358112 |
You HJ et al. | A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358156 |
Kim DC et al. | Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16182255 |
Kojima K et al. | Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18789895 |
Cristóvão AC et al. | PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23827392 |
Chintalgattu V and Katwa LC | Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19540196 |
Shin EJ et al. | Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. | 2012 | Behav. Brain Res. | pmid:22512859 |
Fryer RM et al. | PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats. | 2002 | Basic Res. Cardiol. | pmid:11998977 |
Xu SZ | Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta. | 2007 | Basic Clin. Pharmacol. Toxicol. | pmid:17927688 |