Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Guo D et al. | Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. | 2012 | Mol. Cell. Neurosci. | pmid:22521536 |
Contreras X et al. | Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages. | 2012 | Retrovirology | pmid:22554282 |
Lee YS and Choi EM | Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells. | 2012 | J. Oral Pathol. Med. | pmid:21958211 |
Brutman-Barazani T et al. | Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes. | 2012 | J. Cell. Biochem. | pmid:22271577 |
Maioli E et al. | Rottlerin and cancer: novel evidence and mechanisms. | 2012 | ScientificWorldJournal | pmid:22272173 |
Lim JH et al. | Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism. | 2012 | Chem. Biol. Interact. | pmid:22410117 |
Hsu YC et al. | Ciliogenic RFX transcription factors regulate FGF1 gene promoter. | 2012 | J. Cell. Biochem. | pmid:22415835 |
Singh BN et al. | Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. | 2012 | Biochem. Pharmacol. | pmid:22902833 |
Chen RX et al. | Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes. | 2012 | Cell. Physiol. Biochem. | pmid:22832358 |
Okuwa H et al. | Sphingosine suppresses mesothelioma cell proliferation by inhibiting PKC-δ and inducing cell cycle arrest at the G(0)/G(1) phase. | 2012 | Cell. Physiol. Biochem. | pmid:23221613 |
Kim YS et al. | Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells. | 2012 | PLoS ONE | pmid:23226259 |
Chen BR et al. | Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. | 2012 | PLoS ONE | pmid:23155470 |
Koh YH et al. | Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells. | 2012 | J. Cell. Mol. Med. | pmid:22040127 |
Jäntti MH et al. | OX1 orexin/hypocretin receptor activation of phospholipase D. | 2012 | Br. J. Pharmacol. | pmid:21718304 |
Schug TT | Targeting transcription through inhibition of TBP. | 2011 Jan-Feb | Oncotarget | pmid:21378415 |
Ko NY et al. | Interleukin-32α production is regulated by MyD88-dependent and independent pathways in IL-1β-stimulated human alveolar epithelial cells. | 2011 Jan-Feb | Immunobiology | pmid:20430472 |
López-Huertas MR et al. | Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes. | 2011 | J. Biol. Chem. | pmid:21669868 |
Pabla N et al. | Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. | 2011 | J. Clin. Invest. | pmid:21633170 |
Valacchi G et al. | Rottlerin exhibits antiangiogenic effects in vitro. | 2011 | Chem Biol Drug Des | pmid:21435184 |
Uruno A et al. | All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. | 2011 | J. Leukoc. Biol. | pmid:21393419 |