Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Liedtke CM and Cole T | Antisense oligodeoxynucleotide to PKC-delta blocks alpha 1-adrenergic activation of Na-K-2Cl cotransport. | 1997 | Am. J. Physiol. | pmid:9374649 |
Keenan C et al. | Isoform specificity of activators and inhibitors of protein kinase C gamma and delta. | 1997 | FEBS Lett. | pmid:9326378 |
Parmer TG et al. | Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells. | 1997 | Cell Growth Differ. | pmid:9056675 |
Gschwendt M et al. | Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. | 1994 | FEBS Lett. | pmid:8307162 |
Gschwendt M et al. | Rottlerin, a novel protein kinase inhibitor. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8123051 |
Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
Mai HN et al. | Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity. | 2019 | Chem. Biol. Interact. | pmid:30393195 |
Chang RS et al. | Unexpected dose response of HaCaT to UVB irradiation. | 2018 | In Vitro Cell. Dev. Biol. Anim. | pmid:30083841 |
Nagai N et al. | Involvement of Endocytosis in the Transdermal Penetration Mechanism of Ketoprofen Nanoparticles. | 2018 | Int J Mol Sci | pmid:30041452 |
Song J et al. | Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines. | 2018 | Mol Med Rep | pmid:30015872 |
Chao H et al. | Activation of bradykinin B2 receptor induced the inflammatory responses of cytosolic phospholipase A after the early traumatic brain injury. | 2018 | Biochim Biophys Acta Mol Basis Dis | pmid:29894755 |
Wang H et al. | Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus. | 2018 | Virol. J. | pmid:29793525 |
Tran HQ et al. | PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT Receptor and Upregulation of Nrf2-Dependent GSH Synthesis. | 2018 | Mol. Neurobiol. | pmid:29468562 |
Tomkova S et al. | In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells. | 2018 | Biochim. Biophys. Acta | pmid:29410069 |
Min M et al. | Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies. | 2017 | PLoS ONE | pmid:29272319 |
Wang Z et al. | Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29203243 |
Shi J et al. | Rottlerin inhibits cell growth, induces apoptosis and cell cycle arrest, and inhibits cell invasion in human hepatocellular carcinoma. | 2018 | Mol Med Rep | pmid:29115596 |
Kuo SW et al. | Intermittent Administration of Parathyroid Hormone 1-34 Enhances Osteogenesis of Human Mesenchymal Stem Cells by Regulating Protein Kinase Cδ. | 2017 | Int J Mol Sci | pmid:29064396 |
Wang X et al. | Dual action of NSC606985 on cell growth and apoptosis mediated through PKCδ in prostatic cancer cells. | 2017 | Int. J. Oncol. | pmid:29048618 |
Sun S et al. | Protein kinase C δ-dependent regulation of Ubiquitin-proteasome system function in breast cancer. | 2017 | Cancer Biomark | pmid:29036789 |