Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Chantara W et al. | Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells. | J Appl Toxicol | pmid:17080406 | |
Chen JS and Song JG | Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells. | 2001 | IUBMB Life | pmid:11419696 |
Mori N et al. | Activation of PKC-δ in HTLV-1-infected T cells. | 2015 | Int. J. Oncol. | pmid:25625567 |
Alapati K et al. | uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells. | 2012 | Int. J. Oncol. | pmid:22641287 |
Wang X et al. | Dual action of NSC606985 on cell growth and apoptosis mediated through PKCδ in prostatic cancer cells. | 2017 | Int. J. Oncol. | pmid:29048618 |
Basu A and Miura A | Differential regulation of extrinsic and intrinsic cell death pathways by protein kinase C. | 2002 | Int. J. Mol. Med. | pmid:12373288 |
Jang BC et al. | Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism. | 2003 | Int. J. Mol. Med. | pmid:14533002 |
Andreeva AY et al. | Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16257565 |
Zhou Y et al. | Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16950644 |
Majewski M et al. | Protein kinase C delta stimulates antigen presentation by Class II MHC in murine dendritic cells. | 2007 | Int. Immunol. | pmid:17446207 |
Pardo J et al. | Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression. | 2003 | Int. Immunol. | pmid:14645153 |
Takizawa T et al. | Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. | 2003 | Int. Arch. Allergy Immunol. | pmid:12771544 |
Narumi K et al. | Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC). | 2012 | Int J Pharm | pmid:22426323 |
Nagai N et al. | Involvement of Endocytosis in the Transdermal Penetration Mechanism of Ketoprofen Nanoparticles. | 2018 | Int J Mol Sci | pmid:30041452 |
Kuo SW et al. | Intermittent Administration of Parathyroid Hormone 1-34 Enhances Osteogenesis of Human Mesenchymal Stem Cells by Regulating Protein Kinase Cδ. | 2017 | Int J Mol Sci | pmid:29064396 |
Sheats MK et al. | In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. | 2015 | Inflammation | pmid:25515270 |
Wadsworth SJ and Goldfine H | Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome. | 2002 | Infect. Immun. | pmid:12117979 |
Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
Chang RS et al. | Unexpected dose response of HaCaT to UVB irradiation. | 2018 | In Vitro Cell. Dev. Biol. Anim. | pmid:30083841 |
Sarkar K et al. | Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells. | 2005 | Immunology | pmid:16313365 |