Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Martin L | The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7. | 2007 | J. Biochem. Mol. Biol. | pmid:17927916 |
Moschella PC et al. | Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells. | 2007 | J. Mol. Cell. Cardiol. | pmid:17976640 |
Marengo B et al. | Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma. | 2008 | Free Radic. Biol. Med. | pmid:17991446 |
Zhang H and Forman HJ | Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18048804 |
Park JA et al. | Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein. | 2007 | Am. J. Pathol. | pmid:18055557 |
McNally AK et al. | Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. | 2008 | Exp. Mol. Pathol. | pmid:18067888 |
Shivshankar P et al. | Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells. | 2008 | Appl. Environ. Microbiol. | pmid:18083882 |
Krutzik PO et al. | High-content single-cell drug screening with phosphospecific flow cytometry. | 2008 | Nat. Chem. Biol. | pmid:18157122 |
Ramnath RD et al. | Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18160487 |
Sud N et al. | Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18192589 |
Olson ER et al. | Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts. | 2008 | Hypertension | pmid:18195168 |
McEneaney V et al. | Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation. | 2008 | Mol. Endocrinol. | pmid:18202152 |
Feng BY et al. | Small-molecule aggregates inhibit amyloid polymerization. | 2008 | Nat. Chem. Biol. | pmid:18223646 |
Torricelli C et al. | Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells. | 2008 | Life Sci. | pmid:18261747 |
Schonhoff CM et al. | Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. | 2008 | Hepatology | pmid:18273864 |
Rishton GM | Aggregator compounds confound amyloid fibrillization assay. | 2008 | Nat. Chem. Biol. | pmid:18277973 |
Park S et al. | Chlorpromazine attenuates pancreatic beta-cell function and mass through IRS2 degradation, while exercise partially reverses the attenuation. | 2008 | J. Psychopharmacol. (Oxford) | pmid:18308779 |
Carraway RE et al. | Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. | 2008 | Regul. Pept. | pmid:18313772 |
Liu N et al. | Erbin-regulated sensitivity of MCF-7 breast cancer cells to TRAIL via ErbB2/AKT/NF-kappaB pathway. | 2008 | J. Biochem. | pmid:18316330 |
Itoh T et al. | Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. | 2008 | Bioorg. Med. Chem. | pmid:18328716 |