Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang Y et al. | Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17625040 |
Miller RL et al. | Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase. | 2007 | Brain Res. | pmid:17662968 |
Kim BC et al. | The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1. | 2007 | J Ethnopharmacol | pmid:17644290 |
Park JA et al. | Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein. | 2007 | Am. J. Pathol. | pmid:18055557 |
Zhao Y et al. | Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin. | 2007 | Cell. Signal. | pmid:17689924 |
Grybko MJ et al. | Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role. | 2007 | J. Leukoc. Biol. | pmid:17077164 |
Springael C et al. | Rottlerin inhibits human T cell responses. | 2007 | Biochem. Pharmacol. | pmid:17141738 |
Kurosu T et al. | Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta. | 2007 | Oncogene | pmid:17130834 |
Shemon AN et al. | Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes. | 2007 | Immunol. Cell Biol. | pmid:17130901 |
Wu SN et al. | Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells. | 2007 | J. Cell. Physiol. | pmid:17133362 |
Mishra R et al. | TGF-beta-regulated collagen type I accumulation: role of Src-based signals. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135298 |
Hassan HA et al. | Regulation of anion exchanger Slc26a6 by protein kinase C. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17151144 |
Burkhart BA et al. | Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure. | 2007 | J. Biol. Chem. | pmid:17158874 |
Choi EY et al. | Involvement of protein kinase Cdelta in iron chelator-induced IL-8 production in human intestinal epithelial cells. | 2007 | Life Sci. | pmid:17097691 |
Ahn BH et al. | Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. | 2007 | Biochim. Biophys. Acta | pmid:17640750 |
Xu SZ | Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta. | 2007 | Basic Clin. Pharmacol. Toxicol. | pmid:17927688 |
Martin L | The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7. | 2007 | J. Biochem. Mol. Biol. | pmid:17927916 |
Klinger JR et al. | Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta. | 2007 | J. Appl. Physiol. | pmid:17901241 |
Kim YH et al. | Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes. | 2007 | Neurobiol. Dis. | pmid:17904375 |
Moschella PC et al. | Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells. | 2007 | J. Mol. Cell. Cardiol. | pmid:17976640 |