Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ahn BK et al. | Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium. | 2006 | J. Invest. Dermatol. | pmid:16575394 |
Mimura Y et al. | Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway. | 2004 | J. Invest. Dermatol. | pmid:15175028 |
Hendey B et al. | Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells. | 2002 | J. Leukoc. Biol. | pmid:11994512 |
Fronhofer V et al. | Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages. | 2006 | J. Leukoc. Biol. | pmid:16330529 |
Kontny E et al. | Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. | 2000 | J. Leukoc. Biol. | pmid:10670587 |
Grybko MJ et al. | Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role. | 2007 | J. Leukoc. Biol. | pmid:17077164 |
Alexander SR et al. | Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils. | 2000 | J. Leukoc. Biol. | pmid:10733103 |
Cronshaw DG et al. | Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22. | 2006 | J. Leukoc. Biol. | pmid:16614259 |
Lee MC et al. | Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages. | 2008 | J. Leukoc. Biol. | pmid:18511573 |
Uruno A et al. | All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. | 2011 | J. Leukoc. Biol. | pmid:21393419 |
Tiwari RL et al. | PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes. | 2014 | J. Lipid Res. | pmid:24792928 |
Ryan AJ et al. | Effect of detergent on "promiscuous" inhibitors. | 2003 | J. Med. Chem. | pmid:12877581 |
Shoichet BK | Interpreting steep dose-response curves in early inhibitor discovery. | 2006 | J. Med. Chem. | pmid:17149857 |
Coan KE et al. | Promiscuous aggregate-based inhibitors promote enzyme unfolding. | 2009 | J. Med. Chem. | pmid:19281222 |
Sugiya H et al. | Role of protein kinase C-delta in isoproterenol-induced amylase release in rat parotid acinar cells. | 2009 | J. Med. Invest. | pmid:20224227 |
Shin SY et al. | Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. | 2004 | J. Mol. Biol. | pmid:15223313 |
Yamanaka K et al. | Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. | 2003 | J. Mol. Cell. Cardiol. | pmid:12818569 |
Wang Y et al. | Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. | 2001 | J. Mol. Cell. Cardiol. | pmid:11708847 |
Moschella PC et al. | Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells. | 2007 | J. Mol. Cell. Cardiol. | pmid:17976640 |
Welters HJ et al. | Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. | 2004 | J. Mol. Endocrinol. | pmid:14766004 |