Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Collins NT et al. | Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16269664 |
Zhao KW et al. | Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. | 2005 | J. Biol. Chem. | pmid:16260419 |
Andreeva AY et al. | Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16257565 |
Wung BS et al. | Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. | 2006 | Pharmacol. Res. | pmid:16243536 |
Payvandi F et al. | Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT. | 2005 | J. Interferon Cytokine Res. | pmid:16241859 |
Kim IS et al. | Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells. | 2005 | FEBS Lett. | pmid:16226254 |
Styles NA et al. | Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C. | 2005 | Neurochem. Int. | pmid:16183168 |
Kim DC et al. | Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16182255 |
Hughes PJ et al. | Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. | 2006 | J. Cell. Biochem. | pmid:16178010 |
Suguro T et al. | Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. | 2006 | Atherosclerosis | pmid:16157345 |
Zhang J et al. | PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. | 2005 | J. Cell. Biochem. | pmid:16114000 |
Brown JM et al. | Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16040631 |
Yamaguchi K et al. | Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. | 2005 | Cancer Chemother. Pharmacol. | pmid:16012865 |
Tepperman BL et al. | Effect of protein kinase C activation on intracellular Ca2+ signaling and integrity of intestinal epithelial cells. | 2005 | Eur. J. Pharmacol. | pmid:16005455 |
Zakharov SI et al. | Activation of the BK (SLO1) potassium channel by mallotoxin. | 2005 | J. Biol. Chem. | pmid:15998639 |
Hsieh HL et al. | BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes. | 2006 | J. Cell. Physiol. | pmid:15991247 |
Avila GE et al. | Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15976015 |
Chen S et al. | Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15955695 |
Skaletz-Rorowski A et al. | PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. | 2005 | Cardiovasc. Res. | pmid:15949478 |
Liao YF et al. | The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade. | 2005 | Life Sci. | pmid:15922001 |
Panaretakis T et al. | Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. | 2005 | Mol. Biol. Cell | pmid:15917298 |
Fan CY et al. | PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy. | 2005 | Biochem. J. | pmid:15913451 |
Roose JP et al. | A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. | 2005 | Mol. Cell. Biol. | pmid:15899849 |
Tse SM et al. | Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. | 2005 | J. Biol. Chem. | pmid:15863503 |
Miguel BG et al. | Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells. | 2005 | Biochim. Biophys. Acta | pmid:15843035 |
Obreja O et al. | Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. | 2005 | Brain | pmid:15817518 |
Hurbin A et al. | Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. | 2005 | J. Biol. Chem. | pmid:15767261 |
Nitti M et al. | Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons. | 2005 | Free Radic. Biol. Med. | pmid:15749380 |
Nabha SM et al. | Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. | 2005 | Oncogene | pmid:15735693 |
Kishida O et al. | Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15723263 |
Ahmed S et al. | Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line. | 2005 | FEBS J. | pmid:15691325 |
Anantharam V et al. | Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15681813 |
Ducroc R et al. | Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. | 2005 | Diabetes | pmid:15677491 |
Rao PE et al. | Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}. | 2005 | J. Immunol. | pmid:15661903 |
Obara K et al. | Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model. | 2005 Jan-Feb | J. Vasc. Res. | pmid:15637442 |
Amos S et al. | Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. | 2005 | J. Biol. Chem. | pmid:15618223 |
Wiedłocha A et al. | Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1. | 2005 | Mol. Biol. Cell | pmid:15574884 |
Woo CH et al. | Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. | 2004 | J. Immunol. | pmid:15557194 |
Kim EH et al. | Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. | 2005 | Oncogene | pmid:15531913 |
Kohro S et al. | Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. | 2004 | Anesth. Analg. | pmid:15502023 |
Tan M et al. | Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15499041 |
Bey EA et al. | Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. | 2004 | J. Immunol. | pmid:15494525 |
Lewis AE et al. | Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. | 2005 | Cell. Signal. | pmid:15494216 |
Woo CH et al. | VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15489375 |
Contreras X et al. | IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes. | 2004 | Microbes Infect. | pmid:15488737 |
You HJ et al. | A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358156 |
Durrant D et al. | The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358112 |
Lladó A et al. | Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. | 2004 | Mol. Biol. Cell | pmid:15342779 |
Deutsch E et al. | Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. | 2004 | J. Virol. | pmid:15331751 |
Wheaton K and Riabowol K | Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. | 2004 | Mol. Cell. Biol. | pmid:15282327 |