Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Bae JH et al. | Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction. | 2012 | Cancer Sci. | pmid:21951556 |
Guo D et al. | Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. | 2012 | Mol. Cell. Neurosci. | pmid:22521536 |
Contreras X et al. | Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages. | 2012 | Retrovirology | pmid:22554282 |
Lee YS and Choi EM | Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells. | 2012 | J. Oral Pathol. Med. | pmid:21958211 |
Brutman-Barazani T et al. | Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes. | 2012 | J. Cell. Biochem. | pmid:22271577 |
Maioli E et al. | Rottlerin and cancer: novel evidence and mechanisms. | 2012 | ScientificWorldJournal | pmid:22272173 |
Sugawara T et al. | PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus. | 2012 | Biochim. Biophys. Acta | pmid:22326427 |
Furuya T et al. | Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor. | 2012 | Curr. Eye Res. | pmid:22335803 |
Deng B et al. | Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits. | 2012 | J. Vasc. Res. | pmid:22261918 |
Chang WT et al. | Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells. | 2012 | Anticancer Res. | pmid:22993309 |
Lei L et al. | Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK). | 2012 | PLoS ONE | pmid:22970301 |
Ku CS et al. | Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. | 2012 | J. Nutr. Biochem. | pmid:22209005 |
Tcatchoff L et al. | Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. | 2012 | PLoS ONE | pmid:22792315 |
Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
Xing AP et al. | Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling. | 2012 | J. Biomed. Biotechnol. | pmid:22754279 |
Maioli E et al. | Rottlerin and curcumin: a comparative analysis. | 2012 | Ann. N. Y. Acad. Sci. | pmid:22758638 |
Narumi K et al. | Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC). | 2012 | Int J Pharm | pmid:22426323 |
Li Z et al. | Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells. | 2012 | Oncol. Rep. | pmid:22427054 |
Alapati K et al. | uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells. | 2012 | Int. J. Oncol. | pmid:22641287 |
Kolasa E et al. | Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene. | 2012 | Toxicol In Vitro | pmid:22643241 |
Yun N et al. | Differential consequences of protein kinase C activation during early and late hepatic ischemic preconditioning. | 2012 | J Physiol Sci | pmid:22359070 |
Lim JH et al. | Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism. | 2012 | Chem. Biol. Interact. | pmid:22410117 |
Hsu YC et al. | Ciliogenic RFX transcription factors regulate FGF1 gene promoter. | 2012 | J. Cell. Biochem. | pmid:22415835 |
Singh BN et al. | Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. | 2012 | Biochem. Pharmacol. | pmid:22902833 |
Chen RX et al. | Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes. | 2012 | Cell. Physiol. Biochem. | pmid:22832358 |
Okuwa H et al. | Sphingosine suppresses mesothelioma cell proliferation by inhibiting PKC-δ and inducing cell cycle arrest at the G(0)/G(1) phase. | 2012 | Cell. Physiol. Biochem. | pmid:23221613 |
Kim YS et al. | Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells. | 2012 | PLoS ONE | pmid:23226259 |
Chen BR et al. | Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. | 2012 | PLoS ONE | pmid:23155470 |
Lin YM et al. | The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. | 2012 | PLoS ONE | pmid:23185512 |
Barrias ES et al. | Trypanosoma cruzi uses macropinocytosis as an additional entry pathway into mammalian host cell. | 2012 | Microbes Infect. | pmid:23010292 |
Hsu JL et al. | Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. | 2012 | Biochem. Pharmacol. | pmid:22490701 |
Lin W et al. | Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation. | 2012 | Eur J Med Chem | pmid:22093759 |
Koh YH et al. | Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells. | 2012 | J. Cell. Mol. Med. | pmid:22040127 |
Jäntti MH et al. | OX1 orexin/hypocretin receptor activation of phospholipase D. | 2012 | Br. J. Pharmacol. | pmid:21718304 |
Schug TT | Targeting transcription through inhibition of TBP. | 2011 Jan-Feb | Oncotarget | pmid:21378415 |
Ko NY et al. | Interleukin-32α production is regulated by MyD88-dependent and independent pathways in IL-1β-stimulated human alveolar epithelial cells. | 2011 Jan-Feb | Immunobiology | pmid:20430472 |
Kim H et al. | EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells. | 2011 | J. Immunother. | pmid:21499124 |
Chung YW et al. | Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. | 2011 | J. Biol. Chem. | pmid:21705328 |
Li S et al. | Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes. | 2011 | Mol. Cell. Neurosci. | pmid:21708260 |
Malla N et al. | Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway. | 2011 | PLoS ONE | pmid:21673806 |
López-Huertas MR et al. | Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes. | 2011 | J. Biol. Chem. | pmid:21669868 |
Pabla N et al. | Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. | 2011 | J. Clin. Invest. | pmid:21633170 |
Valacchi G et al. | Rottlerin exhibits antiangiogenic effects in vitro. | 2011 | Chem Biol Drug Des | pmid:21435184 |
Uruno A et al. | All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. | 2011 | J. Leukoc. Biol. | pmid:21393419 |
Ku CS et al. | Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells. | 2011 | Nutr Res | pmid:21530801 |
Kim YR et al. | Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation. | 2011 | Cell Biochem. Biophys. | pmid:21468691 |
Leverence JT et al. | Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation. | 2011 | Chem. Biol. Interact. | pmid:20920494 |
Park EJ and Kwon TK | Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. | 2011 | Exp. Mol. Med. | pmid:21971413 |
Koh YH et al. | Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. | 2011 | J. Cell. Mol. Med. | pmid:20973912 |
Chen Z et al. | Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors. | 2011 | Endocr. Relat. Cancer | pmid:21990324 |
Prast-Nielsen S et al. | Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay. | 2011 | Free Radic. Biol. Med. | pmid:21262347 |
da Silva Cunha KC et al. | A phospholipase Aâ‚‚ isolated from Lachesis muta snake venom increases the survival of retinal ganglion cells in vitro. | 2011 | Toxicon | pmid:21223976 |
Lee SE et al. | Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells. | 2011 | Toxicol. Lett. | pmid:21238556 |
Yang QE et al. | Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. | 2011 | Biol. Reprod. | pmid:21191110 |
Barbaric I et al. | High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival. | 2011 | J Biomol Screen | pmid:21593487 |
Matta C et al. | PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures. | 2011 | Biochimie | pmid:20850497 |
Zhang D et al. | Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21310168 |
Lim SC et al. | Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. | 2011 | Carcinogenesis | pmid:21362627 |
Wermuth PJ et al. | Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. | 2011 | PLoS ONE | pmid:22096525 |
Tsai RK et al. | PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. | 2011 | Mol. Vis. | pmid:21738386 |
Lawal AO and Ellis EM | Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells. | 2011 | Environ. Toxicol. Pharmacol. | pmid:21787730 |
Clements RT et al. | Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts. | 2011 | Circulation | pmid:21911819 |
Sarkar N et al. | Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. | 2011 | Biochim. Biophys. Acta | pmid:21723915 |
Shirasugi I et al. | Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. | 2010 | Biosci. Biotechnol. Biochem. | pmid:21071833 |
Das J et al. | Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. | 2010 | PLoS ONE | pmid:20830294 |
Filone CM et al. | Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. | 2010 | PLoS ONE | pmid:21124804 |
Wang Y et al. | Protein kinase C regulates urea permeability in the rat inner medullary collecting duct. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20861079 |
Tang CH et al. | The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts. | 2010 | Arthritis Rheum. | pmid:20862675 |
Xie MJ et al. | Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ. | 2010 | Clin. Exp. Pharmacol. Physiol. | pmid:20880184 |
Jiang W et al. | [Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells]. | 2010 | Hua Xi Kou Qiang Yi Xue Za Zhi | pmid:21179694 |
Kim KM et al. | Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20060010 |
Ohno I et al. | Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19762431 |
Lin CJ et al. | Rottlerin inhibits migration of follicular thyroid carcinoma cells by PKCdelta-independent destabilization of the focal adhesion complex. | 2010 | J. Cell. Biochem. | pmid:20225271 |
Li X et al. | PKC-delta promotes renal tubular cell apoptosis associated with proteinuria. | 2010 | J. Am. Soc. Nephrol. | pmid:20395372 |
Mertens-Walker I et al. | Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}. | 2010 | Endocr. Relat. Cancer | pmid:20215102 |
Park EJ et al. | Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells. | 2010 | Biochimie | pmid:19833168 |
Leppänen T et al. | Inhibition of protein kinase Cdelta reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages. | 2010 | Eur. J. Pharmacol. | pmid:19925787 |
Bhatt KH et al. | Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro. | 2010 | Mol. Immunol. | pmid:19931912 |
Rohilla A et al. | Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts. | 2010 | Biomed. Pharmacother. | pmid:19914792 |
Shen SM et al. | Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells. | 2010 | Carcinogenesis | pmid:20015864 |
McEneaney V et al. | Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:19804826 |
Behl M et al. | Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C. | 2010 | Neurotoxicology | pmid:20488202 |
Hwang YP et al. | 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression. | 2010 | Toxicol. Lett. | pmid:20599481 |
Lanaspa MA et al. | The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. | 2010 | J. Biol. Chem. | pmid:20639513 |
Maioli E and Valacchi G | Rottlerin: bases for a possible usage in psoriasis. | 2010 | Curr. Drug Metab. | pmid:20540694 |
Arisaka M et al. | Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells. | 2010 | FEBS Lett. | pmid:20122929 |
Wallerstedt E et al. | Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells. | 2010 | Diabetologia | pmid:20151299 |
Liu J et al. | The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells. | 2010 | J Tissue Eng Regen Med | pmid:20033927 |
Shumilina E et al. | Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. | 2010 | Cell. Physiol. Biochem. | pmid:21063107 |
Lee HG and Yang JH | PKC-δ mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner. | 2010 | Chemosphere | pmid:20846705 |
Hufnagel H et al. | Fluid phase endocytosis contributes to transfection of DNA by PEI-25. | 2009 | Mol. Ther. | pmid:19532143 |
Chintalgattu V and Katwa LC | Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19540196 |
Fordjour AK and Harrington EO | PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function. | 2009 | Biochim. Biophys. Acta | pmid:19632305 |
Fan Y et al. | Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation. | 2009 | Neurosci Bull | pmid:19633700 |
Esper RM and Loeb JA | Neurotrophins induce neuregulin release through protein kinase Cdelta activation. | 2009 | J. Biol. Chem. | pmid:19648576 |
Zhao M et al. | Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells. | 2009 | PLoS ONE | pmid:19662097 |
Park SK et al. | Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. | 2009 | Carcinogenesis | pmid:19420016 |
Matsuoka H et al. | Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways. | 2009 | Exp. Cell Res. | pmid:19393235 |
Di Rosa M et al. | Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. | 2009 | J. Cell. Biochem. | pmid:19415692 |
Sugiya H et al. | Role of protein kinase C-delta in isoproterenol-induced amylase release in rat parotid acinar cells. | 2009 | J. Med. Invest. | pmid:20224227 |