Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Palmer TM and Stiles GL | Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms. | 1999 | Biochemistry | pmid:10555965 |
Basu A and Akkaraju GR | Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C. | 1999 | Biochemistry | pmid:10194341 |
Chao H et al. | Activation of bradykinin B2 receptor induced the inflammatory responses of cytosolic phospholipase A after the early traumatic brain injury. | 2018 | Biochim Biophys Acta Mol Basis Dis | pmid:29894755 |
Tapia JA et al. | Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism. | 2006 | Biochim. Biophys. Acta | pmid:16364465 |
Miguel BG et al. | Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells. | 2005 | Biochim. Biophys. Acta | pmid:15843035 |
Tomkova S et al. | In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells. | 2018 | Biochim. Biophys. Acta | pmid:29410069 |
Cho SI et al. | Novel compounds, '1,3-selenazine derivatives' as specific inhibitors of eukaryotic elongation factor-2 kinase. | 2000 | Biochim. Biophys. Acta | pmid:10913818 |
Sugawara T et al. | PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus. | 2012 | Biochim. Biophys. Acta | pmid:22326427 |
Ahn BH et al. | Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. | 2007 | Biochim. Biophys. Acta | pmid:17640750 |
Liu CY et al. | Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA. | 2009 | Biochim. Biophys. Acta | pmid:19477272 |
Fordjour AK and Harrington EO | PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function. | 2009 | Biochim. Biophys. Acta | pmid:19632305 |
Sarkar N et al. | Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. | 2011 | Biochim. Biophys. Acta | pmid:21723915 |
Choi YA et al. | Integrin signaling and cell spreading alterations by rottlerin treatment of chick limb bud mesenchymal cells. | 2009 | Biochimie | pmid:19306958 |
Park EJ et al. | Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells. | 2010 | Biochimie | pmid:19833168 |
Matta C et al. | PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures. | 2011 | Biochimie | pmid:20850497 |
Kaur K et al. | Possible mechanism of rottlerin induced modulation of ischemia reperfusion injury in isolated rat hearts. | 2008 | Biol. Pharm. Bull. | pmid:18758070 |
Budnik LT and Mukhopadhyay AK | Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone. | 2002 | Biol. Reprod. | pmid:12193405 |
Yang QE et al. | Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. | 2011 | Biol. Reprod. | pmid:21191110 |
Tuorkey MJ | Cancer Therapy with Phytochemicals: Present and Future Perspectives. | 2015 | Biomed. Environ. Sci. | pmid:26695359 |
Rohilla A et al. | Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts. | 2010 | Biomed. Pharmacother. | pmid:19914792 |
Rohilla A and Balakumar P | The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta. | 2009 | Biomed. Pharmacother. | pmid:19914793 |
Itoh T et al. | Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. | 2008 | Bioorg. Med. Chem. | pmid:18328716 |
Shirasugi I et al. | Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. | 2010 | Biosci. Biotechnol. Biochem. | pmid:21071833 |
Pula G et al. | PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. | 2006 | Blood | pmid:16940418 |
Yamaguchi R et al. | Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. | 2016 | Blood Cells Mol. Dis. | pmid:26852662 |
Ni H et al. | Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. | 2003 | Br. J. Haematol. | pmid:12786795 |
Cho JY et al. | Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. | 2003 | Br. J. Pharmacol. | pmid:12970105 |
Jäntti MH et al. | OX1 orexin/hypocretin receptor activation of phospholipase D. | 2012 | Br. J. Pharmacol. | pmid:21718304 |
Obreja O et al. | Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. | 2005 | Brain | pmid:15817518 |
Miller RL et al. | Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase. | 2007 | Brain Res. | pmid:17662968 |
Lishmanov YB et al. | Involvement of Protein Kinase C-δ in the Realization of Cardioprotective Effect of Ischemic Postconditioning. | 2016 | Bull. Exp. Biol. Med. | pmid:27496038 |
Sun S et al. | Protein kinase C δ-dependent regulation of Ubiquitin-proteasome system function in breast cancer. | 2017 | Cancer Biomark | pmid:29036789 |
Kishida O et al. | Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15723263 |
Yamaguchi K et al. | Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. | 2005 | Cancer Chemother. Pharmacol. | pmid:16012865 |
Shanmugam M et al. | A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction. | 2001 | Cancer Lett. | pmid:11595128 |
Daveri E et al. | Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. | 2016 | Cancer Lett. | pmid:27343979 |
Torricelli C et al. | Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. | 2015 | Cancer Lett. | pmid:25661734 |
Oh JI et al. | Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. | 2005 | Cancer Lett. | pmid:16297709 |
Zhu M et al. | Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes. | 2006 | Cancer Lett. | pmid:16455194 |
Kumar D et al. | Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. | 2014 | Cancer Lett. | pmid:24125861 |
Huang M et al. | Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. | 2014 | Cancer Lett. | pmid:25050737 |
Basu A et al. | Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway. | 2008 | Cancer Res. | pmid:18413747 |
Tillman DM et al. | Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. | 2003 | Cancer Res. | pmid:12941843 |
Clark AS et al. | Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. | 2003 | Cancer Res. | pmid:12591726 |
Kurosu T et al. | Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. | 2009 | Cancer Res. | pmid:19366808 |
Bae JH et al. | Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction. | 2012 | Cancer Sci. | pmid:21951556 |
Lin CW et al. | Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. | 2008 | Carcinogenesis | pmid:18628248 |
Kang JH et al. | Plasma protein kinase C (PKC)alpha as a biomarker for the diagnosis of cancers. | 2009 | Carcinogenesis | pmid:19710177 |
Lim JH et al. | Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells. | 2009 | Carcinogenesis | pmid:19037087 |
Park SK et al. | Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. | 2009 | Carcinogenesis | pmid:19420016 |
Shen SM et al. | Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells. | 2010 | Carcinogenesis | pmid:20015864 |
Lim SC et al. | Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. | 2011 | Carcinogenesis | pmid:21362627 |
Szilagyi K et al. | PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages. | 2014 | Cardiovasc. Res. | pmid:25253077 |
Skaletz-Rorowski A et al. | PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. | 2005 | Cardiovasc. Res. | pmid:15949478 |
Zatta AJ et al. | Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling. | 2006 | Cardiovasc. Res. | pmid:16443207 |
Schreckenberg R et al. | Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. | 2004 | Cardiovasc. Res. | pmid:15276481 |
Kim YR et al. | Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation. | 2011 | Cell Biochem. Biophys. | pmid:21468691 |
Nakatake M et al. | STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells. | 2007 | Cell Cycle | pmid:17525530 |
Basu A et al. | Involvement of protein kinase C-delta in DNA damage-induced apoptosis. | 2001 | Cell Death Differ. | pmid:11526445 |
Hasima N and Ozpolat B | Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. | 2014 | Cell Death Dis | pmid:25375374 |
Lee YJ et al. | Protein kinase Cdelta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest. | 2002 | Cell Growth Differ. | pmid:12065247 |
Parmer TG et al. | Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells. | 1997 | Cell Growth Differ. | pmid:9056675 |
Mok SA et al. | A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures. | 2009 | Cell Res. | pmid:19188931 |
Song BW et al. | Protein kinase C activation stimulates mesenchymal stem cell adhesion through activation of focal adhesion kinase. | 2013 | Cell Transplant | pmid:23006313 |
Bierhals K et al. | The epsilon-isoform of PKC mediates the hypertonic activation of cation channels in confluent monolayers of rat hepatocytes. | 2007 | Cell. Physiol. Biochem. | pmid:17762167 |
Matschke V et al. | The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. | 2016 | Cell. Physiol. Biochem. | pmid:27997884 |
Mischitelli M et al. | Stimulation of Suicidal Erythrocyte Death by Rottlerin. | 2016 | Cell. Physiol. Biochem. | pmid:27889758 |
Chen RX et al. | Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes. | 2012 | Cell. Physiol. Biochem. | pmid:22832358 |
Okuwa H et al. | Sphingosine suppresses mesothelioma cell proliferation by inhibiting PKC-δ and inducing cell cycle arrest at the G(0)/G(1) phase. | 2012 | Cell. Physiol. Biochem. | pmid:23221613 |
Shumilina E et al. | Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. | 2010 | Cell. Physiol. Biochem. | pmid:21063107 |
Goon Goh F et al. | G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes. | 2008 | Cell. Signal. | pmid:18424071 |
Zhao Y et al. | Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin. | 2007 | Cell. Signal. | pmid:17689924 |
Lewis AE et al. | Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. | 2005 | Cell. Signal. | pmid:15494216 |
Deszo EL et al. | IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta. | 2004 | Cell. Signal. | pmid:14636897 |
Lu W et al. | Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells. | 2014 | Cell. Signal. | pmid:24607787 |
Valacchi G et al. | Rottlerin exhibits antiangiogenic effects in vitro. | 2011 | Chem Biol Drug Des | pmid:21435184 |
Leverence JT et al. | Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation. | 2011 | Chem. Biol. Interact. | pmid:20920494 |
Lim JH et al. | Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism. | 2012 | Chem. Biol. Interact. | pmid:22410117 |
Mai HN et al. | Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity. | 2019 | Chem. Biol. Interact. | pmid:30393195 |
Maddox JF et al. | Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. | 2003 | Chem. Res. Toxicol. | pmid:12755590 |
Lee HG and Yang JH | PKC-δ mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner. | 2010 | Chemosphere | pmid:20846705 |
Sussmann M et al. | Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. | 2004 | Circ. Res. | pmid:14752026 |
Clements RT et al. | Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts. | 2011 | Circulation | pmid:21911819 |
Dang DK et al. | Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA. | 2015 | Clin. Exp. Pharmacol. Physiol. | pmid:25400014 |
Xie MJ et al. | Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ. | 2010 | Clin. Exp. Pharmacol. Physiol. | pmid:20880184 |
Maioli E and Valacchi G | Rottlerin: bases for a possible usage in psoriasis. | 2010 | Curr. Drug Metab. | pmid:20540694 |
Furuya T et al. | Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor. | 2012 | Curr. Eye Res. | pmid:22335803 |
Bull ND et al. | Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. | 2007 | Curr. Eye Res. | pmid:17364745 |
Lee NR et al. | Cytokine secreted by S100A9 via TLR4 in monocytes delays neutrophil apoptosis by inhibition of caspase 9/3 pathway. | 2016 | Cytokine | pmid:27459393 |
Lee JS et al. | House dust mite, Dermatophagoides pteronissinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells. | 2008 | Cytokine | pmid:18490175 |
Hagelkruys A et al. | A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. | 2014 | Development | pmid:24449838 |
Ducroc R et al. | Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. | 2005 | Diabetes | pmid:15677491 |
Ross R et al. | Hypothalamic protein kinase C regulates glucose production. | 2008 | Diabetes | pmid:18511848 |
Kim YH et al. | Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway. | 2008 | Diabetes | pmid:18443201 |
Wallerstedt E et al. | Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells. | 2010 | Diabetologia | pmid:20151299 |
Huang SP et al. | Ethambutol induces impaired autophagic flux and apoptosis in the rat retina. | 2015 | Dis Model Mech | pmid:26092127 |
Zhang X et al. | NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. | 2005 | EMBO J. | pmid:16319926 |
Chen Z et al. | Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors. | 2011 | Endocr. Relat. Cancer | pmid:21990324 |
Mertens-Walker I et al. | Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}. | 2010 | Endocr. Relat. Cancer | pmid:20215102 |
Bureik M et al. | Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors. | 2002 | Endocr. Res. | pmid:12530636 |