Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Tsai RK et al. | PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. | 2011 | Mol. Vis. | pmid:21738386 |
Nakajima T et al. | Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines. | 2006 | Mutat. Res. | pmid:16337250 |
Takahashi A et al. | Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. | 2006 | Nat. Cell Biol. | pmid:17028578 |
Krutzik PO et al. | High-content single-cell drug screening with phosphospecific flow cytometry. | 2008 | Nat. Chem. Biol. | pmid:18157122 |
Feng BY et al. | Small-molecule aggregates inhibit amyloid polymerization. | 2008 | Nat. Chem. Biol. | pmid:18223646 |
Rishton GM | Aggregator compounds confound amyloid fibrillization assay. | 2008 | Nat. Chem. Biol. | pmid:18277973 |
Kim YH et al. | Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes. | 2007 | Neurobiol. Dis. | pmid:17904375 |
Styles NA et al. | Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C. | 2005 | Neurochem. Int. | pmid:16183168 |
Nguyen KT et al. | Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes. | 2009 | Neurochem. Res. | pmid:19495968 |
Fan Y et al. | Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation. | 2009 | Neurosci Bull | pmid:19633700 |