Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Contreras X et al. | IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes. | 2004 | Microbes Infect. | pmid:15488737 |
Kohro S et al. | Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. | 2004 | Anesth. Analg. | pmid:15502023 |
Bey EA et al. | Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. | 2004 | J. Immunol. | pmid:15494525 |
Tan M et al. | Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15499041 |
Welters HJ et al. | Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. | 2004 | J. Mol. Endocrinol. | pmid:14766004 |
Anantharam V et al. | Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15681813 |
Huda R et al. | Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle. | 2004 | Shock | pmid:15167677 |
Bazuine M et al. | Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes. | 2004 | Biochem. Pharmacol. | pmid:15183122 |
Iwabu A et al. | Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. | 2004 | J. Biol. Chem. | pmid:14747473 |
Sussmann M et al. | Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. | 2004 | Circ. Res. | pmid:14752026 |
Kajimoto T et al. | Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex. | 2004 | J. Biol. Chem. | pmid:14715667 |
Woo CH et al. | Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. | 2004 | J. Immunol. | pmid:15557194 |
Kang HS et al. | Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. | 2004 | Mol. Cells | pmid:15232218 |
Lladó A et al. | Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. | 2004 | Mol. Biol. Cell | pmid:15342779 |
Cho CH et al. | Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:14704231 |
Nishizawa S et al. | Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. | 2003 Mar-Apr | J. Vasc. Res. | pmid:12808353 |
Liedtke CM et al. | Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells. | 2003 | Am. J. Physiol., Cell Physiol. | pmid:12388079 |
Tan M et al. | Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. | 2003 | J. Biol. Chem. | pmid:12431976 |
Kim HJ et al. | The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. | 2003 | J. Biol. Chem. | pmid:12403780 |
Kitazawa M et al. | Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. | 2003 | Neuroscience | pmid:12831855 |
Matthews V et al. | Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). | 2003 | J. Biol. Chem. | pmid:12832423 |
Shukla A et al. | Asbestos-induced apoptosis is protein kinase C delta-dependent. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12626342 |
Gore-Hyer E et al. | Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. | 2003 | Arthritis Rheum. | pmid:12632435 |
Saraiva L et al. | Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta. | 2003 | J Enzyme Inhib Med Chem | pmid:15008511 |
Ni H et al. | Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. | 2003 | Br. J. Haematol. | pmid:12786795 |
Wang Q et al. | Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. | 2003 | J. Biol. Chem. | pmid:14527959 |
Wrede CE et al. | Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). | 2003 | J. Mol. Endocrinol. | pmid:12790799 |
Deb DK et al. | Activation of protein kinase C delta by IFN-gamma. | 2003 | J. Immunol. | pmid:12817007 |
Yamanaka K et al. | Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. | 2003 | J. Mol. Cell. Cardiol. | pmid:12818569 |
Kitamura K et al. | The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression. | 2003 | Genes Cells | pmid:12653960 |
Cho JY et al. | Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. | 2003 | Br. J. Pharmacol. | pmid:12970105 |
Tillman DM et al. | Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. | 2003 | Cancer Res. | pmid:12941843 |
Trushin SA et al. | Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. | 2003 | Mol. Cell. Biol. | pmid:12972622 |
Choe Y et al. | Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones. | 2003 | J. Neuroendocrinol. | pmid:12694376 |
McCracken MA et al. | Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. | 2003 | Mol. Cancer Ther. | pmid:12657722 |
Blanquet PR et al. | A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. | 2003 | Neuroscience | pmid:12699783 |
Harrington EO et al. | Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12707019 |
Wang L et al. | Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. | 2003 | Biochem. J. | pmid:12720544 |
Huwiler A et al. | Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12732207 |
Hock MB and Brown MA | Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness. | 2003 | J. Biol. Chem. | pmid:12738787 |
Maddox JF et al. | Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. | 2003 | Chem. Res. Toxicol. | pmid:12755590 |
Frank GD et al. | Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta. | 2003 | Mol. Cell. Biol. | pmid:12588978 |
Clark AS et al. | Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. | 2003 | Cancer Res. | pmid:12591726 |
Minami T et al. | Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. | 2003 | J. Biol. Chem. | pmid:12493764 |
Ryan AJ et al. | Effect of detergent on "promiscuous" inhibitors. | 2003 | J. Med. Chem. | pmid:12877581 |
Domenicotti C et al. | Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. | 2003 | Free Radic. Biol. Med. | pmid:12927600 |
Xu K et al. | A generic time-resolved fluorescence assay for serine/threonine kinase activity: application to Cdc7/Dbf4. | 2003 | J. Biochem. Mol. Biol. | pmid:12895303 |
Miskolci V et al. | Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils. | 2003 | Arch. Biochem. Biophys. | pmid:12921778 |
Susarla BT and Robinson MB | Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. | 2003 | J. Neurochem. | pmid:12859677 |
Glaser S et al. | Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12505882 |
Ham YM et al. | The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. | 2003 | J. Biol. Chem. | pmid:14514687 |
Pardo J et al. | Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression. | 2003 | Int. Immunol. | pmid:14645153 |
Jang BC et al. | Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism. | 2003 | Int. J. Mol. Med. | pmid:14533002 |
Domenicotti C et al. | A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion. | 2003 | Biochem. Pharmacol. | pmid:14555230 |
Takizawa T et al. | Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. | 2003 | Int. Arch. Allergy Immunol. | pmid:12771544 |
Erclik MS and Mitchell J | The role of protein kinase C-delta in PTH stimulation of IGF-binding protein-5 mRNA in UMR-106-01 cells. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11832354 |
Zhao H et al. | Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:11880333 |
Anantharam V et al. | Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. | 2002 | J. Neurosci. | pmid:11880503 |
Sumitomo M et al. | Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. | 2002 | J. Clin. Invest. | pmid:11901191 |
Todt JC et al. | Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages. | 2002 | J. Biol. Chem. | pmid:12114511 |
Lange Y et al. | Effect of protein kinase C on endoplasmic reticulum cholesterol. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779197 |
Blass M et al. | Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. | 2002 | Mol. Cell. Biol. | pmid:11739733 |
Han JM et al. | Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. | 2002 | J. Biol. Chem. | pmid:11744693 |
Kucich U et al. | Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:11804868 |
Li B et al. | Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. | 2002 | J. Biol. Chem. | pmid:11796722 |
Basu A et al. | Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway. | 2002 | Exp. Cell Res. | pmid:12169276 |
Cruciani V and Mikalsen SO | Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts. | 2002 | Toxicol. Appl. Pharmacol. | pmid:12127264 |
Budnik LT and Mukhopadhyay AK | Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone. | 2002 | Biol. Reprod. | pmid:12193405 |
Wadsworth SJ and Goldfine H | Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome. | 2002 | Infect. Immun. | pmid:12117979 |
Hendey B et al. | Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells. | 2002 | J. Leukoc. Biol. | pmid:11994512 |
Fryer RM et al. | PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats. | 2002 | Basic Res. Cardiol. | pmid:11998977 |
Ghelli A et al. | Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. | 2002 | Biochem. J. | pmid:12014986 |
Liedtke CM et al. | Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11943682 |
Kudo M et al. | Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12063302 |
Lee YJ et al. | Protein kinase Cdelta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest. | 2002 | Cell Growth Differ. | pmid:12065247 |
Bull ND and Barnett NL | Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ. | 2002 | J. Neurochem. | pmid:12065656 |
Liu JF et al. | FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054499 |
Kilpatrick LE et al. | A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:12055072 |
Cipriani B et al. | Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens. | 2002 | J. Immunol. | pmid:12421956 |
Kayali AG et al. | Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. | 2002 | Endocrinology | pmid:12239100 |
Saito S et al. | Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. | 2002 | J. Biol. Chem. | pmid:12226102 |
Niwa K et al. | Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells. | 2002 | Free Radic. Res. | pmid:12592666 |
Bureik M et al. | Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors. | 2002 | Endocr. Res. | pmid:12530636 |
Johnson CL et al. | Regulation of p53 stabilization by DNA damage and protein kinase C. | 2002 | Mol. Cancer Ther. | pmid:12492119 |
Pickett CA et al. | Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells. | 2002 | Mol. Endocrinol. | pmid:12456804 |
Hai CM et al. | Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells. | 2002 | Exp. Cell Res. | pmid:12372340 |
Basu A and Miura A | Differential regulation of extrinsic and intrinsic cell death pathways by protein kinase C. | 2002 | Int. J. Mol. Med. | pmid:12373288 |
Lesage GD et al. | Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity. | 2002 | Hepatology | pmid:12198656 |
Fryer RM et al. | Essential activation of PKC-delta in opioid-initiated cardioprotection. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179083 |
Chen JH et al. | Rottlerin stimulates metallothionein gene expression but inhibits metal transport in Chinese hamster ovary cells. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11749125 |
Wang GY et al. | Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11602672 |
Vancurova I et al. | NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha. | 2001 | J. Biol. Chem. | pmid:11274209 |
Solomou EE et al. | Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. | 2001 | J. Immunol. | pmid:11313407 |
Morino K et al. | Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta. | 2001 | Endocrinology | pmid:11356718 |
Braiman L et al. | Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle. | 2001 | Mol. Endocrinol. | pmid:11266508 |
Leung CH et al. | PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11444839 |
Dietrich C et al. | Rottlerin induces a transformed phenotype in human keratinocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401499 |
Noya F et al. | p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7. | 2001 | J. Virol. | pmid:11390614 |
Wang Y et al. | Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. | 2001 | J. Mol. Cell. Cardiol. | pmid:11708847 |
Bankers-Fulbright JL et al. | Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta. | 2001 | J. Cell. Physiol. | pmid:11748588 |