Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
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Authors | Title | Published | Journal | PubMed Link |
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Kitazawa M et al. | Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. | 2003 | Neuroscience | pmid:12831855 |
Matthews V et al. | Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). | 2003 | J. Biol. Chem. | pmid:12832423 |
Shukla A et al. | Asbestos-induced apoptosis is protein kinase C delta-dependent. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12626342 |
Gore-Hyer E et al. | Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. | 2003 | Arthritis Rheum. | pmid:12632435 |
Domenicotti C et al. | Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. | 2003 | Free Radic. Biol. Med. | pmid:12927600 |
Xu K et al. | A generic time-resolved fluorescence assay for serine/threonine kinase activity: application to Cdc7/Dbf4. | 2003 | J. Biochem. Mol. Biol. | pmid:12895303 |
Miskolci V et al. | Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils. | 2003 | Arch. Biochem. Biophys. | pmid:12921778 |
Susarla BT and Robinson MB | Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. | 2003 | J. Neurochem. | pmid:12859677 |
Pardo J et al. | Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression. | 2003 | Int. Immunol. | pmid:14645153 |
Jang BC et al. | Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism. | 2003 | Int. J. Mol. Med. | pmid:14533002 |
Domenicotti C et al. | A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion. | 2003 | Biochem. Pharmacol. | pmid:14555230 |
Nishizawa S et al. | Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. | 2003 Mar-Apr | J. Vasc. Res. | pmid:12808353 |
Kohro S et al. | Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. | 2004 | Anesth. Analg. | pmid:15502023 |
Bey EA et al. | Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. | 2004 | J. Immunol. | pmid:15494525 |
Tan M et al. | Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15499041 |
Wheaton K and Riabowol K | Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. | 2004 | Mol. Cell. Biol. | pmid:15282327 |
Schreckenberg R et al. | Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. | 2004 | Cardiovasc. Res. | pmid:15276481 |
Chintalgattu V and Katwa LC | Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15240825 |
Li C et al. | Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15217780 |
Shin SY et al. | Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. | 2004 | J. Mol. Biol. | pmid:15223313 |