| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim H et al. | EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells. | 2011 | J. Immunother. | pmid:21499124 |
| Leverence JT et al. | Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation. | 2011 | Chem. Biol. Interact. | pmid:20920494 |
| Koh YH et al. | Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. | 2011 | J. Cell. Mol. Med. | pmid:20973912 |
| Chen Z et al. | Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors. | 2011 | Endocr. Relat. Cancer | pmid:21990324 |
| Prast-Nielsen S et al. | Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay. | 2011 | Free Radic. Biol. Med. | pmid:21262347 |
| da Silva Cunha KC et al. | A phospholipase Aâ‚‚ isolated from Lachesis muta snake venom increases the survival of retinal ganglion cells in vitro. | 2011 | Toxicon | pmid:21223976 |
| Lee SE et al. | Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells. | 2011 | Toxicol. Lett. | pmid:21238556 |
| Yang QE et al. | Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. | 2011 | Biol. Reprod. | pmid:21191110 |
| Barbaric I et al. | High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival. | 2011 | J Biomol Screen | pmid:21593487 |
| Matta C et al. | PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures. | 2011 | Biochimie | pmid:20850497 |