rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Edema D004487 152 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Glomerulonephritis D005921 35 associated lipids
Cardiomegaly D006332 31 associated lipids
Hypertrophy D006984 16 associated lipids
Kidney Diseases D007674 29 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Tsai RK et al. PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. 2011 Mol. Vis. pmid:21738386
Nakajima T et al. Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines. 2006 Mutat. Res. pmid:16337250
Takahashi A et al. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. 2006 Nat. Cell Biol. pmid:17028578
Krutzik PO et al. High-content single-cell drug screening with phosphospecific flow cytometry. 2008 Nat. Chem. Biol. pmid:18157122
Feng BY et al. Small-molecule aggregates inhibit amyloid polymerization. 2008 Nat. Chem. Biol. pmid:18223646
Rishton GM Aggregator compounds confound amyloid fibrillization assay. 2008 Nat. Chem. Biol. pmid:18277973
Kim YH et al. Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes. 2007 Neurobiol. Dis. pmid:17904375
Styles NA et al. Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C. 2005 Neurochem. Int. pmid:16183168
Nguyen KT et al. Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes. 2009 Neurochem. Res. pmid:19495968
Fan Y et al. Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation. 2009 Neurosci Bull pmid:19633700
Lee SD et al. Bradykinin activates phospholipase D2 via protein kinase cdelta in PC12 cells. 2000 Neurosci. Lett. pmid:11058804
Sheean RK et al. Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin. 2013 Neuroscience pmid:24095695
Kitazawa M et al. Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. 2003 Neuroscience pmid:12831855
Blanquet PR et al. A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. 2003 Neuroscience pmid:12699783
Behl M et al. Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C. 2010 Neurotoxicology pmid:20488202
Kim BH et al. Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophages. 2007 Nov-Dec Nitric Oxide pmid:17651994
Ku CS et al. Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells. 2011 Nutr Res pmid:21530801
Heit I et al. Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblasts. 2001 Oncogene pmid:11526503
Nabha SM et al. Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. 2005 Oncogene pmid:15735693
Kim EH et al. Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. 2005 Oncogene pmid:15531913