rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Prostatic Neoplasms D011471 126 associated lipids
Parkinson Disease D010300 53 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia D007938 74 associated lipids
Kidney Diseases D007674 29 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Morino K et al. Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta. 2001 Endocrinology pmid:11356718
Kayali AG et al. Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. 2002 Endocrinology pmid:12239100
Lawal AO and Ellis EM Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells. 2011 Environ. Toxicol. Pharmacol. pmid:21787730
Lin CC et al. Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. 2015 Enzyme Microb. Technol. pmid:25435499
Lin W et al. Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation. 2012 Eur J Med Chem pmid:22093759
Brutkiewicz RR et al. Protein kinase C delta is a critical regulator of CD1d-mediated antigen presentation. 2007 Eur. J. Immunol. pmid:17705133
Shimamura K et al. Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. 2004 Eur. J. Pharmacol. pmid:14975703
Tepperman BL et al. Effect of protein kinase C activation on intracellular Ca2+ signaling and integrity of intestinal epithelial cells. 2005 Eur. J. Pharmacol. pmid:16005455
Samokhin GP et al. Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets. 1999 Eur. J. Pharmacol. pmid:10618482
Leppänen T et al. Inhibition of protein kinase Cdelta reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages. 2010 Eur. J. Pharmacol. pmid:19925787
Basu A et al. Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway. 2002 Exp. Cell Res. pmid:12169276
Hai CM et al. Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells. 2002 Exp. Cell Res. pmid:12372340
Gao FH et al. Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. 2009 Exp. Cell Res. pmid:19747914
Matsuoka H et al. Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways. 2009 Exp. Cell Res. pmid:19393235
Wang P et al. Relaxin Inhibits Cardiac Fibrosis in Diabetic Rats: Roles of Protein Kinase Cδ. 2018 Exp. Clin. Endocrinol. Diabetes pmid:28895644
Valacchi G et al. Rottlerin: a multifaced regulator of keratinocyte cell cycle. 2009 Exp. Dermatol. pmid:19492998
Dreixler JC et al. Protein kinase C subtypes and retinal ischemic preconditioning. 2008 Exp. Eye Res. pmid:18722601
Kawabata H et al. A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. 2015 Exp. Hematol. pmid:25633564
Byun HS et al. Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase. 2008 Exp. Mol. Med. pmid:18446057
Park EJ and Kwon TK Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. 2011 Exp. Mol. Med. pmid:21971413