rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Prostatic Neoplasms D011471 126 associated lipids
Parkinson Disease D010300 53 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia D007938 74 associated lipids
Kidney Diseases D007674 29 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Yamanaka K et al. Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. 2003 J. Mol. Cell. Cardiol. pmid:12818569
Kitamura K et al. The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression. 2003 Genes Cells pmid:12653960
Cho JY et al. Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. 2003 Br. J. Pharmacol. pmid:12970105
Tillman DM et al. Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. 2003 Cancer Res. pmid:12941843
Trushin SA et al. Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. 2003 Mol. Cell. Biol. pmid:12972622
Choe Y et al. Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones. 2003 J. Neuroendocrinol. pmid:12694376
McCracken MA et al. Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. 2003 Mol. Cancer Ther. pmid:12657722
Blanquet PR et al. A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. 2003 Neuroscience pmid:12699783
Harrington EO et al. Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12707019
Wang L et al. Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. 2003 Biochem. J. pmid:12720544
Huwiler A et al. Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. 2003 Biochem. Biophys. Res. Commun. pmid:12732207
Nishizawa S et al. Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. 2003 Mar-Apr J. Vasc. Res. pmid:12808353
Frank DE and Carter WG Laminin 5 deposition regulates keratinocyte polarization and persistent migration. 2004 J. Cell. Sci. pmid:14996912
Shimamura K et al. Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. 2004 Eur. J. Pharmacol. pmid:14975703
Rao VU et al. PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:14975926
Kumar Biswas S et al. Down-regulation of Bcl-2 is associated with cisplatin resistance in human small cell lung cancer H69 cells. 2004 Mol. Cancer Ther. pmid:15026553
Huda R et al. Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle. 2004 Shock pmid:15167677
Bazuine M et al. Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes. 2004 Biochem. Pharmacol. pmid:15183122
Deszo EL et al. IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta. 2004 Cell. Signal. pmid:14636897
Ryazanova LV et al. Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. 2004 J. Biol. Chem. pmid:14594813