| MeSH term | MeSH ID | Detail |
|---|---|---|
| Psoriasis | D011565 | 47 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Das J et al. | Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. | 2010 | PLoS ONE | pmid:20830294 |
| Filone CM et al. | Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. | 2010 | PLoS ONE | pmid:21124804 |
| Jiang W et al. | [Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells]. | 2010 | Hua Xi Kou Qiang Yi Xue Za Zhi | pmid:21179694 |
| Ohno I et al. | Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19762431 |
| Maioli E and Valacchi G | Rottlerin: bases for a possible usage in psoriasis. | 2010 | Curr. Drug Metab. | pmid:20540694 |
| Arisaka M et al. | Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells. | 2010 | FEBS Lett. | pmid:20122929 |
| Wallerstedt E et al. | Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells. | 2010 | Diabetologia | pmid:20151299 |
| Liu J et al. | The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells. | 2010 | J Tissue Eng Regen Med | pmid:20033927 |
| Shumilina E et al. | Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. | 2010 | Cell. Physiol. Biochem. | pmid:21063107 |
| Lee HG and Yang JH | PKC-δ mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner. | 2010 | Chemosphere | pmid:20846705 |
| Suzuki T and Hara H | Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. | 2009 | J. Nutr. | pmid:19297429 |
| Kurosu T et al. | Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. | 2009 | Cancer Res. | pmid:19366808 |
| Satoh K et al. | Phosphorylation of myristoylated alanine-rich C kinase substrate is involved in the cAMP-dependent amylase release in parotid acinar cells. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19372103 |
| Lima F et al. | Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. | 2009 | Mol. Biol. Cell | pmid:19339281 |
| Park SK et al. | Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. | 2009 | Carcinogenesis | pmid:19420016 |
| Matsuoka H et al. | Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways. | 2009 | Exp. Cell Res. | pmid:19393235 |
| Di Rosa M et al. | Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. | 2009 | J. Cell. Biochem. | pmid:19415692 |
| Sugiya H et al. | Role of protein kinase C-delta in isoproterenol-induced amylase release in rat parotid acinar cells. | 2009 | J. Med. Invest. | pmid:20224227 |
| Kato K et al. | Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells. | 2009 | Am. J. Physiol. Heart Circ. Physiol. | pmid:19837952 |
| Rohilla A and Balakumar P | The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta. | 2009 | Biomed. Pharmacother. | pmid:19914793 |