Chen ZF et al. |
[The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. |
2006 |
Zhonghua Zhong Liu Za Zhi |
pmid:17236547
|
Fan Y et al. |
[Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell]. |
2006 |
Zhonghua Yi Xue Za Zhi |
pmid:17313780
|
Wang H et al. |
Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus. |
2018 |
Virol. J. |
pmid:29793525
|
Mendonça MC et al. |
Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells. |
2012 Sep-Oct |
Vascul. Pharmacol. |
pmid:22583821
|
Soltoff SP |
Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta. |
2007 |
Trends Pharmacol. Sci. |
pmid:17692392
|
da Silva Cunha KC et al. |
A phospholipase Aâ‚‚ isolated from Lachesis muta snake venom increases the survival of retinal ganglion cells in vitro. |
2011 |
Toxicon |
pmid:21223976
|
So KY and Oh SH |
Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells. |
2016 |
Toxicology |
pmid:27658547
|
Lee SE et al. |
Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells. |
2011 |
Toxicol. Lett. |
pmid:21238556
|
Hwang YP et al. |
3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression. |
2010 |
Toxicol. Lett. |
pmid:20599481
|
Kim MH et al. |
EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. |
2017 |
Toxicol. Appl. Pharmacol. |
pmid:27939242
|
Chen JH et al. |
Rottlerin stimulates metallothionein gene expression but inhibits metal transport in Chinese hamster ovary cells. |
2001 |
Toxicol. Appl. Pharmacol. |
pmid:11749125
|
Cruciani V and Mikalsen SO |
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts. |
2002 |
Toxicol. Appl. Pharmacol. |
pmid:12127264
|
Yang JH et al. |
Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. |
2014 |
Toxicol. Appl. Pharmacol. |
pmid:24211276
|
Kim KM et al. |
Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. |
2010 |
Toxicol. Appl. Pharmacol. |
pmid:20060010
|
Zhang D et al. |
Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line. |
2011 |
Toxicol. Appl. Pharmacol. |
pmid:21310168
|
Kolasa E et al. |
Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene. |
2012 |
Toxicol In Vitro |
pmid:22643241
|
Jang BC |
Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion. |
2009 |
Toxicol In Vitro |
pmid:19084589
|
Prudnikova TY and Chernoff J |
The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. |
2017 |
Small GTPases |
pmid:27427770
|
Huda R et al. |
Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle. |
2004 |
Shock |
pmid:15167677
|
Gangwar M et al. |
Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study. |
2014 |
ScientificWorldJournal |
pmid:25525615
|
Maioli E et al. |
Rottlerin and cancer: novel evidence and mechanisms. |
2012 |
ScientificWorldJournal |
pmid:22272173
|
Ietta F et al. |
Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells. |
2017 |
Sci Rep |
pmid:28455500
|
Serrero M et al. |
PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production. |
2017 |
Sci Rep |
pmid:28539656
|
Guan X et al. |
Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. |
2017 |
Sci Rep |
pmid:28165042
|
Contreras X et al. |
Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages. |
2012 |
Retrovirology |
pmid:22554282
|
Yang QE et al. |
The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development. |
2016 |
Reprod. Fertil. Dev. |
pmid:25116760
|
Carraway RE et al. |
Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. |
2008 |
Regul. Pept. |
pmid:18313772
|
Hassan S et al. |
Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells. |
2004 |
Regul. Pept. |
pmid:15177934
|
Liao TY et al. |
Rottlerin impairs the formation and maintenance of psychostimulant-supported memory. |
2016 |
Psychopharmacology (Berl.) |
pmid:26960698
|
Yu HS et al. |
Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway. |
2013 |
Prostate |
pmid:22653778
|
Min M et al. |
Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies. |
2017 |
PLoS ONE |
pmid:29272319
|
Das J et al. |
Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. |
2010 |
PLoS ONE |
pmid:20830294
|
Filone CM et al. |
Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. |
2010 |
PLoS ONE |
pmid:21124804
|
Malla N et al. |
Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway. |
2011 |
PLoS ONE |
pmid:21673806
|
Xie L et al. |
Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. |
2016 |
PLoS ONE |
pmid:27442243
|
Atef ME and Anand-Srivastava MB |
Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats. |
2016 |
PLoS ONE |
pmid:27379421
|
Chen Q et al. |
PKCδ and θ possibly mediate FSH-induced mouse oocyte maturation via NOX-ROS-TACE cascade signaling pathway. |
2014 |
PLoS ONE |
pmid:25350560
|
Naskar S et al. |
Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy. |
2014 |
PLoS ONE |
pmid:25116170
|
Lei L et al. |
Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK). |
2012 |
PLoS ONE |
pmid:22970301
|
Tcatchoff L et al. |
Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. |
2012 |
PLoS ONE |
pmid:22792315
|
Balgi AD et al. |
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. |
2009 |
PLoS ONE |
pmid:19771169
|
Kim YS et al. |
Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells. |
2012 |
PLoS ONE |
pmid:23226259
|
Leppänen T et al. |
Down-regulation of protein kinase Cδ inhibits inducible nitric oxide synthase expression through IRF1. |
2013 |
PLoS ONE |
pmid:23326354
|
Chen BR et al. |
Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. |
2012 |
PLoS ONE |
pmid:23155470
|
Zhao M et al. |
Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells. |
2009 |
PLoS ONE |
pmid:19662097
|
Meehan AC et al. |
Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition. |
2013 |
PLoS ONE |
pmid:23555904
|
Lee SJ et al. |
PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model. |
2013 |
PLoS ONE |
pmid:23441159
|
Lin YM et al. |
The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. |
2012 |
PLoS ONE |
pmid:23185512
|
Khor EC et al. |
Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption. |
2013 |
PLoS ONE |
pmid:23951014
|
Fenyvesi F et al. |
Fluorescently labeled methyl-beta-cyclodextrin enters intestinal epithelial Caco-2 cells by fluid-phase endocytosis. |
2014 |
PLoS ONE |
pmid:24416301
|
Wermuth PJ et al. |
Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. |
2011 |
PLoS ONE |
pmid:22096525
|
Juneja M et al. |
Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. |
2017 |
PLoS Biol. |
pmid:28570591
|
Chan TK et al. |
Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models. |
2013 |
Phytomedicine |
pmid:23632085
|
Misuth M et al. |
Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. |
2017 |
Photodiagnosis Photodyn Ther |
pmid:28373118
|
Xu H et al. |
Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. |
2015 |
Pharmacology |
pmid:26021525
|
Wung BS et al. |
Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. |
2006 |
Pharmacol. Res. |
pmid:16243536
|
Thrower EC et al. |
Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini. |
2009 |
Pancreas |
pmid:19752773
|
Song P et al. |
PKCδ promotes high glucose induced renal tubular oxidative damage via regulating activation and translocation of p66Shc. |
2014 |
Oxid Med Cell Longev |
pmid:25371776
|
Zhao Z et al. |
Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer. |
2017 |
Oncotarget |
pmid:27999199
|
Wang L et al. |
Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. |
2016 |
Oncotarget |
pmid:27626499
|
Yin X et al. |
Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells. |
2016 |
Oncotarget |
pmid:27582552
|
Zhu Y et al. |
Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma. |
2017 |
Oncotarget |
pmid:28423559
|
Schug TT |
Targeting transcription through inhibition of TBP. |
2011 Jan-Feb |
Oncotarget |
pmid:21378415
|
Faria CC et al. |
Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma. |
2015 |
Oncotarget |
pmid:26061748
|
Li Z et al. |
Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells. |
2012 |
Oncol. Rep. |
pmid:22427054
|
Heit I et al. |
Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblasts. |
2001 |
Oncogene |
pmid:11526503
|
Nabha SM et al. |
Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. |
2005 |
Oncogene |
pmid:15735693
|
Cross T et al. |
PKC-delta is an apoptotic lamin kinase. |
2000 |
Oncogene |
pmid:10822384
|
Kurosu T et al. |
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta. |
2007 |
Oncogene |
pmid:17130834
|
Kim EH et al. |
Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. |
2005 |
Oncogene |
pmid:15531913
|
Ku CS et al. |
Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells. |
2011 |
Nutr Res |
pmid:21530801
|
Kim BH et al. |
Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophages. |
2007 Nov-Dec |
Nitric Oxide |
pmid:17651994
|
Behl M et al. |
Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C. |
2010 |
Neurotoxicology |
pmid:20488202
|
Sheean RK et al. |
Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin. |
2013 |
Neuroscience |
pmid:24095695
|
Kitazawa M et al. |
Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. |
2003 |
Neuroscience |
pmid:12831855
|
Blanquet PR et al. |
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. |
2003 |
Neuroscience |
pmid:12699783
|
Lee SD et al. |
Bradykinin activates phospholipase D2 via protein kinase cdelta in PC12 cells. |
2000 |
Neurosci. Lett. |
pmid:11058804
|
Fan Y et al. |
Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation. |
2009 |
Neurosci Bull |
pmid:19633700
|
Nguyen KT et al. |
Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes. |
2009 |
Neurochem. Res. |
pmid:19495968
|
Styles NA et al. |
Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C. |
2005 |
Neurochem. Int. |
pmid:16183168
|
Kim YH et al. |
Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes. |
2007 |
Neurobiol. Dis. |
pmid:17904375
|
Krutzik PO et al. |
High-content single-cell drug screening with phosphospecific flow cytometry. |
2008 |
Nat. Chem. Biol. |
pmid:18157122
|
Feng BY et al. |
Small-molecule aggregates inhibit amyloid polymerization. |
2008 |
Nat. Chem. Biol. |
pmid:18223646
|
Rishton GM |
Aggregator compounds confound amyloid fibrillization assay. |
2008 |
Nat. Chem. Biol. |
pmid:18277973
|
Takahashi A et al. |
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. |
2006 |
Nat. Cell Biol. |
pmid:17028578
|
Nakajima T et al. |
Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines. |
2006 |
Mutat. Res. |
pmid:16337250
|
Tsai RK et al. |
PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. |
2011 |
Mol. Vis. |
pmid:21738386
|
Hufnagel H et al. |
Fluid phase endocytosis contributes to transfection of DNA by PEI-25. |
2009 |
Mol. Ther. |
pmid:19532143
|
Tran HQ et al. |
PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT Receptor and Upregulation of Nrf2-Dependent GSH Synthesis. |
2018 |
Mol. Neurobiol. |
pmid:29468562
|
Kwon MJ et al. |
Role of PKCdelta in IFN-gamma-inducible CIITA gene expression. |
2007 |
Mol. Immunol. |
pmid:17346795
|
Bhatt KH et al. |
Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro. |
2010 |
Mol. Immunol. |
pmid:19931912
|
Jackson TA et al. |
Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCdelta. |
2001 |
Mol. Endocrinol. |
pmid:11518800
|
McEneaney V et al. |
Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation. |
2008 |
Mol. Endocrinol. |
pmid:18202152
|
Braiman L et al. |
Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle. |
2001 |
Mol. Endocrinol. |
pmid:11266508
|
Pickett CA et al. |
Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells. |
2002 |
Mol. Endocrinol. |
pmid:12456804
|
Braiman L et al. |
Protein kinase Cdelta mediates insulin-induced glucose transport in primary cultures of rat skeletal muscle. |
1999 |
Mol. Endocrinol. |
pmid:10598577
|
Peters CA et al. |
Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. |
2000 |
Mol. Endocrinol. |
pmid:10770494
|
Kang HS et al. |
Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. |
2004 |
Mol. Cells |
pmid:15232218
|
Li S et al. |
Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes. |
2011 |
Mol. Cell. Neurosci. |
pmid:21708260
|
Guo D et al. |
Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. |
2012 |
Mol. Cell. Neurosci. |
pmid:22521536
|