|
|
|
|
pmid:
|
Chantara W et al. |
Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells. |
|
J Appl Toxicol |
pmid:17080406
|
BACKHOUSE T and McGOOKIN A |
Rottlerin; the synthesis of tetrahydrorottlerin and of tetrahydroallorottlerin and the reversibility of the rottlerone change. |
1948 |
J Chem Soc |
pmid:18906365
|
Gschwendt M et al. |
Rottlerin, a novel protein kinase inhibitor. |
1994 |
Biochem. Biophys. Res. Commun. |
pmid:8123051
|
Gschwendt M et al. |
Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. |
1994 |
FEBS Lett. |
pmid:8307162
|
Liedtke CM and Cole T |
Antisense oligodeoxynucleotide to PKC-delta blocks alpha 1-adrenergic activation of Na-K-2Cl cotransport. |
1997 |
Am. J. Physiol. |
pmid:9374649
|
Keenan C et al. |
Isoform specificity of activators and inhibitors of protein kinase C gamma and delta. |
1997 |
FEBS Lett. |
pmid:9326378
|
Parmer TG et al. |
Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells. |
1997 |
Cell Growth Differ. |
pmid:9056675
|
Braiman L et al. |
Protein kinase Cdelta mediates insulin-induced glucose transport in primary cultures of rat skeletal muscle. |
1999 |
Mol. Endocrinol. |
pmid:10598577
|
Song JC et al. |
PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS. |
1999 |
Am. J. Physiol. |
pmid:10600776
|
Samokhin GP et al. |
Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets. |
1999 |
Eur. J. Pharmacol. |
pmid:10618482
|
Palmer TM and Stiles GL |
Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms. |
1999 |
Biochemistry |
pmid:10555965
|
Villalba M et al. |
Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death. |
1999 |
J. Immunol. |
pmid:10570264
|
Bheekha-Escura R et al. |
Pharmacologic regulation of histamine release by the human recombinant histamine-releasing factor. |
1999 |
J. Allergy Clin. Immunol. |
pmid:10329832
|
Corbit KC et al. |
Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells. |
1999 |
Mol. Cell. Biol. |
pmid:10330161
|
Chen N et al. |
Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis. |
1999 |
J. Biol. Chem. |
pmid:10336426
|
Basu A and Akkaraju GR |
Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C. |
1999 |
Biochemistry |
pmid:10194341
|
Hornia A et al. |
Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. |
1999 |
Mol. Cell. Biol. |
pmid:10523655
|
Reyland ME et al. |
Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells. |
1999 |
J. Biol. Chem. |
pmid:10383415
|
Efimova T and Eckert RL |
Regulation of human involucrin promoter activity by novel protein kinase C isoforms. |
2000 |
J. Biol. Chem. |
pmid:10636851
|
Cross T et al. |
PKC-delta is an apoptotic lamin kinase. |
2000 |
Oncogene |
pmid:10822384
|
Peters CA et al. |
Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. |
2000 |
Mol. Endocrinol. |
pmid:10770494
|
Kilpatrick LE et al. |
Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils. |
2000 |
Am. J. Physiol., Cell Physiol. |
pmid:11078718
|
Lee SD et al. |
Bradykinin activates phospholipase D2 via protein kinase cdelta in PC12 cells. |
2000 |
Neurosci. Lett. |
pmid:11058804
|
Wert MM and Palfrey HC |
Divergence in the anti-apoptotic signalling pathways used by nerve growth factor and basic fibroblast growth factor (bFGF) in PC12 cells: rescue by bFGF involves protein kinase C delta. |
2000 |
Biochem. J. |
pmid:11062070
|
Chen NY et al. |
Activation of PKC is required for arsenite-induced signal transduction. |
2000 |
J. Environ. Pathol. Toxicol. Oncol. |
pmid:10983896
|
Wen HC and Lin WW |
Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells. |
2000 |
J. Cell. Biochem. |
pmid:10996851
|
Meacci E et al. |
Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. |
2000 |
FEBS Lett. |
pmid:11018530
|
Gallagher HC et al. |
Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta. |
2000 |
J. Neurosci. Res. |
pmid:10972960
|
Cho SI et al. |
Novel compounds, '1,3-selenazine derivatives' as specific inhibitors of eukaryotic elongation factor-2 kinase. |
2000 |
Biochim. Biophys. Acta |
pmid:10913818
|
Kontny E et al. |
Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. |
2000 |
J. Leukoc. Biol. |
pmid:10670587
|
Alexander SR et al. |
Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils. |
2000 |
J. Leukoc. Biol. |
pmid:10733103
|
Davies SP et al. |
Specificity and mechanism of action of some commonly used protein kinase inhibitors. |
2000 |
Biochem. J. |
pmid:10998351
|
Fryer RM et al. |
Essential activation of PKC-delta in opioid-initiated cardioprotection. |
2001 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:11179083
|
De Witt BJ et al. |
Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. |
2001 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:11133494
|
Takahashi T and Shibuya M |
The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells. |
2001 |
Biochem. Biophys. Res. Commun. |
pmid:11162532
|
Shanmugam M et al. |
A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction. |
2001 |
Cancer Lett. |
pmid:11595128
|
Wakino S et al. |
Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells. |
2001 |
J. Biol. Chem. |
pmid:11598137
|
Jimenez SA et al. |
Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. |
2001 |
J. Clin. Invest. |
pmid:11696585
|
Grandvaux N et al. |
Oxidant-dependent phosphorylation of p40phox in B lymphocytes. |
2001 |
Biochem. Biophys. Res. Commun. |
pmid:11573965
|
Basu A et al. |
Involvement of protein kinase C-delta in DNA damage-induced apoptosis. |
2001 |
Cell Death Differ. |
pmid:11526445
|
Heit I et al. |
Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblasts. |
2001 |
Oncogene |
pmid:11526503
|
Thabard W et al. |
Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells. |
2001 |
Biochem. J. |
pmid:11485567
|
Masur K et al. |
High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. |
2001 |
Mol. Biol. Cell |
pmid:11451996
|
Jackson TA et al. |
Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCdelta. |
2001 |
Mol. Endocrinol. |
pmid:11518800
|
Soltoff SP |
Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation. |
2001 |
J. Biol. Chem. |
pmid:11498535
|
Leitges M et al. |
Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells. |
2001 |
Lab. Invest. |
pmid:11502860
|
Chen JH et al. |
Rottlerin stimulates metallothionein gene expression but inhibits metal transport in Chinese hamster ovary cells. |
2001 |
Toxicol. Appl. Pharmacol. |
pmid:11749125
|
Wang GY et al. |
Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes. |
2001 |
J. Pharmacol. Exp. Ther. |
pmid:11602672
|
Vancurova I et al. |
NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha. |
2001 |
J. Biol. Chem. |
pmid:11274209
|
Solomou EE et al. |
Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. |
2001 |
J. Immunol. |
pmid:11313407
|
Morino K et al. |
Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta. |
2001 |
Endocrinology |
pmid:11356718
|
Braiman L et al. |
Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle. |
2001 |
Mol. Endocrinol. |
pmid:11266508
|
Leung CH et al. |
PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF. |
2001 |
Biochem. Biophys. Res. Commun. |
pmid:11444839
|
Dietrich C et al. |
Rottlerin induces a transformed phenotype in human keratinocytes. |
2001 |
Biochem. Biophys. Res. Commun. |
pmid:11401499
|
Noya F et al. |
p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7. |
2001 |
J. Virol. |
pmid:11390614
|
Wang Y et al. |
Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. |
2001 |
J. Mol. Cell. Cardiol. |
pmid:11708847
|
Chen JS and Song JG |
Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells. |
2001 |
IUBMB Life |
pmid:11419696
|
Bankers-Fulbright JL et al. |
Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta. |
2001 |
J. Cell. Physiol. |
pmid:11748588
|
Erclik MS and Mitchell J |
The role of protein kinase C-delta in PTH stimulation of IGF-binding protein-5 mRNA in UMR-106-01 cells. |
2002 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:11832354
|
Zhao H et al. |
Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion. |
2002 |
Am. J. Physiol. Renal Physiol. |
pmid:11880333
|
Anantharam V et al. |
Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. |
2002 |
J. Neurosci. |
pmid:11880503
|
Sumitomo M et al. |
Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. |
2002 |
J. Clin. Invest. |
pmid:11901191
|
Todt JC et al. |
Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages. |
2002 |
J. Biol. Chem. |
pmid:12114511
|
Lange Y et al. |
Effect of protein kinase C on endoplasmic reticulum cholesterol. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:11779197
|
Blass M et al. |
Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. |
2002 |
Mol. Cell. Biol. |
pmid:11739733
|
Han JM et al. |
Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. |
2002 |
J. Biol. Chem. |
pmid:11744693
|
Kucich U et al. |
Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38. |
2002 |
Am. J. Respir. Cell Mol. Biol. |
pmid:11804868
|
Li B et al. |
Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. |
2002 |
J. Biol. Chem. |
pmid:11796722
|
Basu A et al. |
Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway. |
2002 |
Exp. Cell Res. |
pmid:12169276
|
Cruciani V and Mikalsen SO |
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts. |
2002 |
Toxicol. Appl. Pharmacol. |
pmid:12127264
|
Budnik LT and Mukhopadhyay AK |
Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone. |
2002 |
Biol. Reprod. |
pmid:12193405
|
Wadsworth SJ and Goldfine H |
Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome. |
2002 |
Infect. Immun. |
pmid:12117979
|
Hendey B et al. |
Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells. |
2002 |
J. Leukoc. Biol. |
pmid:11994512
|
Fryer RM et al. |
PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats. |
2002 |
Basic Res. Cardiol. |
pmid:11998977
|
Ghelli A et al. |
Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. |
2002 |
Biochem. J. |
pmid:12014986
|
Liedtke CM et al. |
Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells. |
2002 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:11943682
|
Kudo M et al. |
Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway. |
2002 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:12063302
|
Lee YJ et al. |
Protein kinase Cdelta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest. |
2002 |
Cell Growth Differ. |
pmid:12065247
|
Bull ND and Barnett NL |
Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ. |
2002 |
J. Neurochem. |
pmid:12065656
|
Liu JF et al. |
FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:12054499
|
Kilpatrick LE et al. |
A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil. |
2002 |
Am. J. Physiol., Cell Physiol. |
pmid:12055072
|
Cipriani B et al. |
Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens. |
2002 |
J. Immunol. |
pmid:12421956
|
Kayali AG et al. |
Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. |
2002 |
Endocrinology |
pmid:12239100
|
Saito S et al. |
Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. |
2002 |
J. Biol. Chem. |
pmid:12226102
|
Niwa K et al. |
Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells. |
2002 |
Free Radic. Res. |
pmid:12592666
|
Bureik M et al. |
Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors. |
2002 |
Endocr. Res. |
pmid:12530636
|
Johnson CL et al. |
Regulation of p53 stabilization by DNA damage and protein kinase C. |
2002 |
Mol. Cancer Ther. |
pmid:12492119
|
Pickett CA et al. |
Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells. |
2002 |
Mol. Endocrinol. |
pmid:12456804
|
Hai CM et al. |
Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells. |
2002 |
Exp. Cell Res. |
pmid:12372340
|
Basu A and Miura A |
Differential regulation of extrinsic and intrinsic cell death pathways by protein kinase C. |
2002 |
Int. J. Mol. Med. |
pmid:12373288
|
Lesage GD et al. |
Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity. |
2002 |
Hepatology |
pmid:12198656
|
Saraiva L et al. |
Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta. |
2003 |
J Enzyme Inhib Med Chem |
pmid:15008511
|
Wang Q et al. |
Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. |
2003 |
J. Biol. Chem. |
pmid:14527959
|
Tillman DM et al. |
Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. |
2003 |
Cancer Res. |
pmid:12941843
|
Trushin SA et al. |
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. |
2003 |
Mol. Cell. Biol. |
pmid:12972622
|
Choe Y et al. |
Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones. |
2003 |
J. Neuroendocrinol. |
pmid:12694376
|
McCracken MA et al. |
Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. |
2003 |
Mol. Cancer Ther. |
pmid:12657722
|
Blanquet PR et al. |
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. |
2003 |
Neuroscience |
pmid:12699783
|
Takizawa T et al. |
Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. |
2003 |
Int. Arch. Allergy Immunol. |
pmid:12771544
|