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Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. |
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Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. |
2004 |
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Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle. |
2004 |
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Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes. |
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IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta. |
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Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. |
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Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. |
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Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. |
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Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. |
2005 |
Oncogene |
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Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. |
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Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. |
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Brain |
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2005 |
Mol. Biol. Cell |
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Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. |
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Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells. |
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Immunology |
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NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. |
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Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT. |
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J. Interferon Cytokine Res. |
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Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. |
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Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. |
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VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium. |
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Am. J. Physiol. Lung Cell Mol. Physiol. |
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Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. |
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PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. |
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Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. |
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Cancer Chemother. Pharmacol. |
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Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}. |
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Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. |
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Diabetes |
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Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line. |
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PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy. |
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Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. |
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Mol. Biol. Cell |
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Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. |
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Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells. |
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Biochim. Biophys. Acta |
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The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade. |
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A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. |
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Activation of the BK (SLO1) potassium channel by mallotoxin. |
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Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice. |
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J. Steroid Biochem. Mol. Biol. |
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Eur. J. Pharmacol. |
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Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. |
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Cancer Chemother. Pharmacol. |
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PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. |
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Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. |
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Biochem. Biophys. Res. Commun. |
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Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C. |
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Neurochem. Int. |
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Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. |
2005 |
Oncogene |
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