| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertrophy | D006984 | 16 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Chlamydia Infections | D002690 | 7 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozpolat B et al. | PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells. | 2007 Sep-Oct | Autophagy | pmid:17507797 |
| Kim BH et al. | Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophages. | 2007 Nov-Dec | Nitric Oxide | pmid:17651994 |
| Chwae YJ et al. | Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C. | 2007 Apr-May | Immunol. Cell Biol. | pmid:17228322 |
| Bain J et al. | The selectivity of protein kinase inhibitors: a further update. | 2007 | Biochem. J. | pmid:17850214 |
| Bierhals K et al. | The epsilon-isoform of PKC mediates the hypertonic activation of cation channels in confluent monolayers of rat hepatocytes. | 2007 | Cell. Physiol. Biochem. | pmid:17762167 |
| Brutkiewicz RR et al. | Protein kinase C delta is a critical regulator of CD1d-mediated antigen presentation. | 2007 | Eur. J. Immunol. | pmid:17705133 |
| Shemon AN et al. | Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes. | 2007 | Immunol. Cell Biol. | pmid:17130901 |
| Wu SN et al. | Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells. | 2007 | J. Cell. Physiol. | pmid:17133362 |
| Mishra R et al. | TGF-beta-regulated collagen type I accumulation: role of Src-based signals. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135298 |
| Hassan HA et al. | Regulation of anion exchanger Slc26a6 by protein kinase C. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17151144 |
| Burkhart BA et al. | Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure. | 2007 | J. Biol. Chem. | pmid:17158874 |
| Choi EY et al. | Involvement of protein kinase Cdelta in iron chelator-induced IL-8 production in human intestinal epithelial cells. | 2007 | Life Sci. | pmid:17097691 |
| Kudirka JC et al. | P2Y nucleotide receptor signaling through MAPK/ERK is regulated by extracellular matrix: involvement of beta3 integrins. | 2007 | J. Cell. Physiol. | pmid:17620283 |
| Xu SZ | Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta. | 2007 | Basic Clin. Pharmacol. Toxicol. | pmid:17927688 |
| Martin L | The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7. | 2007 | J. Biochem. Mol. Biol. | pmid:17927916 |
| Klinger JR et al. | Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta. | 2007 | J. Appl. Physiol. | pmid:17901241 |
| Kim YH et al. | Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes. | 2007 | Neurobiol. Dis. | pmid:17904375 |
| Moschella PC et al. | Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells. | 2007 | J. Mol. Cell. Cardiol. | pmid:17976640 |
| Guo B et al. | Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. | 2007 | J. Immunol. | pmid:17404251 |
| Akar U et al. | Tissue transglutaminase inhibits autophagy in pancreatic cancer cells. | 2007 | Mol. Cancer Res. | pmid:17374730 |