rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Glomerulonephritis D005921 35 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Cardiomegaly D006332 31 associated lipids
Kidney Diseases D007674 29 associated lipids
Glioblastoma D005909 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with rottlerin

Download all related citations
Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Ozpolat B et al. PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells. 2007 Sep-Oct Autophagy pmid:17507797
Kim BH et al. Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophages. 2007 Nov-Dec Nitric Oxide pmid:17651994
Chwae YJ et al. Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C. 2007 Apr-May Immunol. Cell Biol. pmid:17228322
Kim YH et al. Expression of cyclin D3 through Sp1 sites by histone deacetylase inhibitors is mediated with protein kinase C-delta (PKC-delta) signal pathway. 2007 J. Cell. Biochem. pmid:17407153
Wang Y et al. Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors. 2007 Am. J. Physiol., Cell Physiol. pmid:17625040
Miller RL et al. Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase. 2007 Brain Res. pmid:17662968
Kim BC et al. The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1. 2007 J Ethnopharmacol pmid:17644290
Park JA et al. Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein. 2007 Am. J. Pathol. pmid:18055557
Zhao Y et al. Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin. 2007 Cell. Signal. pmid:17689924
Grybko MJ et al. Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role. 2007 J. Leukoc. Biol. pmid:17077164
Springael C et al. Rottlerin inhibits human T cell responses. 2007 Biochem. Pharmacol. pmid:17141738
Kurosu T et al. Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta. 2007 Oncogene pmid:17130834
Shemon AN et al. Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes. 2007 Immunol. Cell Biol. pmid:17130901
Wu SN et al. Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells. 2007 J. Cell. Physiol. pmid:17133362
Mishra R et al. TGF-beta-regulated collagen type I accumulation: role of Src-based signals. 2007 Am. J. Physiol., Cell Physiol. pmid:17135298
Hassan HA et al. Regulation of anion exchanger Slc26a6 by protein kinase C. 2007 Am. J. Physiol., Cell Physiol. pmid:17151144
Burkhart BA et al. Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure. 2007 J. Biol. Chem. pmid:17158874
Ahn BH et al. Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. 2007 Biochim. Biophys. Acta pmid:17640750
Xu SZ Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta. 2007 Basic Clin. Pharmacol. Toxicol. pmid:17927688
Martin L The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7. 2007 J. Biochem. Mol. Biol. pmid:17927916