| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glomerulonephritis | D005921 | 35 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Krutzik PO et al. | High-content single-cell drug screening with phosphospecific flow cytometry. | 2008 | Nat. Chem. Biol. | pmid:18157122 |
| Ramnath RD et al. | Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18160487 |
| Torricelli C et al. | Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells. | 2008 | Life Sci. | pmid:18261747 |
| Sud N et al. | Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18192589 |
| Olson ER et al. | Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts. | 2008 | Hypertension | pmid:18195168 |
| Carraway RE et al. | Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. | 2008 | Regul. Pept. | pmid:18313772 |
| Itoh T et al. | Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. | 2008 | Bioorg. Med. Chem. | pmid:18328716 |
| Rishton GM | Aggregator compounds confound amyloid fibrillization assay. | 2008 | Nat. Chem. Biol. | pmid:18277973 |
| Longpre JM and Loo G | Protection of human colon epithelial cells against deoxycholate by rottlerin. | 2008 | Apoptosis | pmid:18661240 |
| Lin CW et al. | Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. | 2008 | Carcinogenesis | pmid:18628248 |
| Ozpolat B et al. | PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells. | 2007 Sep-Oct | Autophagy | pmid:17507797 |
| Kim BH et al. | Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophages. | 2007 Nov-Dec | Nitric Oxide | pmid:17651994 |
| Chwae YJ et al. | Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C. | 2007 Apr-May | Immunol. Cell Biol. | pmid:17228322 |
| Majewski M et al. | Protein kinase C delta stimulates antigen presentation by Class II MHC in murine dendritic cells. | 2007 | Int. Immunol. | pmid:17446207 |
| Kwon MJ et al. | Role of PKCdelta in IFN-gamma-inducible CIITA gene expression. | 2007 | Mol. Immunol. | pmid:17346795 |
| Kim YH et al. | Expression of cyclin D3 through Sp1 sites by histone deacetylase inhibitors is mediated with protein kinase C-delta (PKC-delta) signal pathway. | 2007 | J. Cell. Biochem. | pmid:17407153 |
| Wang Y et al. | Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17625040 |
| Miller RL et al. | Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase. | 2007 | Brain Res. | pmid:17662968 |
| Kim BC et al. | The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1. | 2007 | J Ethnopharmacol | pmid:17644290 |
| Park JA et al. | Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein. | 2007 | Am. J. Pathol. | pmid:18055557 |
| Bain J et al. | The selectivity of protein kinase inhibitors: a further update. | 2007 | Biochem. J. | pmid:17850214 |
| Bierhals K et al. | The epsilon-isoform of PKC mediates the hypertonic activation of cation channels in confluent monolayers of rat hepatocytes. | 2007 | Cell. Physiol. Biochem. | pmid:17762167 |
| Zhao Y et al. | Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin. | 2007 | Cell. Signal. | pmid:17689924 |
| Thomas R and Kim MH | Targeting the hypoxia inducible factor pathway with mitochondrial uncouplers. | 2007 | Mol. Cell. Biochem. | pmid:16924414 |
| Grybko MJ et al. | Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role. | 2007 | J. Leukoc. Biol. | pmid:17077164 |
| Springael C et al. | Rottlerin inhibits human T cell responses. | 2007 | Biochem. Pharmacol. | pmid:17141738 |
| Kurosu T et al. | Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta. | 2007 | Oncogene | pmid:17130834 |
| Shemon AN et al. | Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes. | 2007 | Immunol. Cell Biol. | pmid:17130901 |
| Wu SN et al. | Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells. | 2007 | J. Cell. Physiol. | pmid:17133362 |
| Mishra R et al. | TGF-beta-regulated collagen type I accumulation: role of Src-based signals. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135298 |
| Hassan HA et al. | Regulation of anion exchanger Slc26a6 by protein kinase C. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17151144 |
| Burkhart BA et al. | Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure. | 2007 | J. Biol. Chem. | pmid:17158874 |
| Choi EY et al. | Involvement of protein kinase Cdelta in iron chelator-induced IL-8 production in human intestinal epithelial cells. | 2007 | Life Sci. | pmid:17097691 |
| Scott DW and Loo G | Curcumin-induced GADD153 upregulation: modulation by glutathione. | 2007 | J. Cell. Biochem. | pmid:17171638 |
| Sun L et al. | Microarray-based kinase inhibition assay by gold nanoparticle probes. | 2007 | Anal. Chem. | pmid:17222050 |
| Gäreskog M and Wentzel P | N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. | 2007 | J. Endocrinol. | pmid:17210758 |
| Ahn BH et al. | Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. | 2007 | Biochim. Biophys. Acta | pmid:17640750 |
| Di Baldassarre A et al. | Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching. | 2007 | J. Cell. Biochem. | pmid:17212360 |
| Xu SZ | Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta. | 2007 | Basic Clin. Pharmacol. Toxicol. | pmid:17927688 |
| Martin L | The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7. | 2007 | J. Biochem. Mol. Biol. | pmid:17927916 |
| Klinger JR et al. | Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta. | 2007 | J. Appl. Physiol. | pmid:17901241 |
| Kim YH et al. | Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes. | 2007 | Neurobiol. Dis. | pmid:17904375 |
| Moschella PC et al. | Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells. | 2007 | J. Mol. Cell. Cardiol. | pmid:17976640 |
| Guo B et al. | Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. | 2007 | J. Immunol. | pmid:17404251 |
| Bull ND et al. | Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. | 2007 | Curr. Eye Res. | pmid:17364745 |
| Kamiya K et al. | Protein kinase C delta activated adhesion regulates vascular smooth muscle cell migration. | 2007 | J. Surg. Res. | pmid:17574042 |
| Nakatake M et al. | STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells. | 2007 | Cell Cycle | pmid:17525530 |
| Pugazhenthi S et al. | Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17535857 |
| Miura T et al. | Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17513490 |
| Zhang D et al. | Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17565007 |