rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Glomerulonephritis D005921 35 associated lipids
Psoriasis D011565 47 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Astrocytoma D001254 15 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Translocation, Genetic D014178 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Nitti M et al. Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons. 2005 Free Radic. Biol. Med. pmid:15749380
Hurbin A et al. Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. 2005 J. Biol. Chem. pmid:15767261
Obreja O et al. Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. 2005 Brain pmid:15817518
Wiedłocha A et al. Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1. 2005 Mol. Biol. Cell pmid:15574884
Amos S et al. Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. 2005 J. Biol. Chem. pmid:15618223
Sarkar K et al. Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells. 2005 Immunology pmid:16313365
Zhang X et al. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. 2005 EMBO J. pmid:16319926
Zhang J et al. PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. 2005 J. Cell. Biochem. pmid:16114000
Brown JM et al. Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16040631
Kishida O et al. Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. 2005 Cancer Chemother. Pharmacol. pmid:15723263
Rao PE et al. Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}. 2005 J. Immunol. pmid:15661903
Ducroc R et al. Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. 2005 Diabetes pmid:15677491
Ahmed S et al. Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line. 2005 FEBS J. pmid:15691325
Fan CY et al. PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy. 2005 Biochem. J. pmid:15913451
Panaretakis T et al. Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. 2005 Mol. Biol. Cell pmid:15917298
Tse SM et al. Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. 2005 J. Biol. Chem. pmid:15863503
Miguel BG et al. Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells. 2005 Biochim. Biophys. Acta pmid:15843035
Liao YF et al. The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade. 2005 Life Sci. pmid:15922001
Roose JP et al. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. 2005 Mol. Cell. Biol. pmid:15899849
Zakharov SI et al. Activation of the BK (SLO1) potassium channel by mallotoxin. 2005 J. Biol. Chem. pmid:15998639