| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glomerulonephritis | D005921 | 35 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huwiler A et al. | Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12732207 |
| Hock MB and Brown MA | Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness. | 2003 | J. Biol. Chem. | pmid:12738787 |
| Maddox JF et al. | Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. | 2003 | Chem. Res. Toxicol. | pmid:12755590 |
| Takizawa T et al. | Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. | 2003 | Int. Arch. Allergy Immunol. | pmid:12771544 |
| Ni H et al. | Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. | 2003 | Br. J. Haematol. | pmid:12786795 |
| Wrede CE et al. | Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). | 2003 | J. Mol. Endocrinol. | pmid:12790799 |
| Nishizawa S et al. | Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. | 2003 Mar-Apr | J. Vasc. Res. | pmid:12808353 |
| Deb DK et al. | Activation of protein kinase C delta by IFN-gamma. | 2003 | J. Immunol. | pmid:12817007 |
| Yamanaka K et al. | Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. | 2003 | J. Mol. Cell. Cardiol. | pmid:12818569 |
| Kitazawa M et al. | Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. | 2003 | Neuroscience | pmid:12831855 |
| Matthews V et al. | Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). | 2003 | J. Biol. Chem. | pmid:12832423 |
| Susarla BT and Robinson MB | Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. | 2003 | J. Neurochem. | pmid:12859677 |
| Ryan AJ et al. | Effect of detergent on "promiscuous" inhibitors. | 2003 | J. Med. Chem. | pmid:12877581 |
| Xu K et al. | A generic time-resolved fluorescence assay for serine/threonine kinase activity: application to Cdc7/Dbf4. | 2003 | J. Biochem. Mol. Biol. | pmid:12895303 |
| Miskolci V et al. | Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils. | 2003 | Arch. Biochem. Biophys. | pmid:12921778 |
| Domenicotti C et al. | Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. | 2003 | Free Radic. Biol. Med. | pmid:12927600 |
| Tillman DM et al. | Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. | 2003 | Cancer Res. | pmid:12941843 |
| Cho JY et al. | Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. | 2003 | Br. J. Pharmacol. | pmid:12970105 |
| Trushin SA et al. | Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. | 2003 | Mol. Cell. Biol. | pmid:12972622 |
| Ham YM et al. | The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. | 2003 | J. Biol. Chem. | pmid:14514687 |
| Wang Q et al. | Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. | 2003 | J. Biol. Chem. | pmid:14527959 |
| Jang BC et al. | Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism. | 2003 | Int. J. Mol. Med. | pmid:14533002 |
| Domenicotti C et al. | A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion. | 2003 | Biochem. Pharmacol. | pmid:14555230 |
| Ryazanova LV et al. | Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. | 2004 | J. Biol. Chem. | pmid:14594813 |
| Deszo EL et al. | IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta. | 2004 | Cell. Signal. | pmid:14636897 |
| Pardo J et al. | Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression. | 2003 | Int. Immunol. | pmid:14645153 |
| Cho CH et al. | Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:14704231 |
| Kajimoto T et al. | Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex. | 2004 | J. Biol. Chem. | pmid:14715667 |
| Iwabu A et al. | Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. | 2004 | J. Biol. Chem. | pmid:14747473 |
| Sussmann M et al. | Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. | 2004 | Circ. Res. | pmid:14752026 |
| Welters HJ et al. | Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. | 2004 | J. Mol. Endocrinol. | pmid:14766004 |
| Shimamura K et al. | Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. | 2004 | Eur. J. Pharmacol. | pmid:14975703 |
| Rao VU et al. | PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:14975926 |
| Frank DE and Carter WG | Laminin 5 deposition regulates keratinocyte polarization and persistent migration. | 2004 | J. Cell. Sci. | pmid:14996912 |
| Saraiva L et al. | Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta. | 2003 | J Enzyme Inhib Med Chem | pmid:15008511 |
| Kumar Biswas S et al. | Down-regulation of Bcl-2 is associated with cisplatin resistance in human small cell lung cancer H69 cells. | 2004 | Mol. Cancer Ther. | pmid:15026553 |
| Blois JT et al. | B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta. | 2004 | J. Biol. Chem. | pmid:15138267 |
| Huda R et al. | Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle. | 2004 | Shock | pmid:15167677 |
| Mimura Y et al. | Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway. | 2004 | J. Invest. Dermatol. | pmid:15175028 |
| Hassan S et al. | Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells. | 2004 | Regul. Pept. | pmid:15177934 |
| Bazuine M et al. | Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes. | 2004 | Biochem. Pharmacol. | pmid:15183122 |
| Li C et al. | Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15217780 |
| Shin SY et al. | Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. | 2004 | J. Mol. Biol. | pmid:15223313 |
| Kang HS et al. | Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. | 2004 | Mol. Cells | pmid:15232218 |
| Chintalgattu V and Katwa LC | Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15240825 |
| Schreckenberg R et al. | Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. | 2004 | Cardiovasc. Res. | pmid:15276481 |
| Cummings R et al. | Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. | 2004 | J. Biol. Chem. | pmid:15280372 |
| Wheaton K and Riabowol K | Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. | 2004 | Mol. Cell. Biol. | pmid:15282327 |
| Deutsch E et al. | Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. | 2004 | J. Virol. | pmid:15331751 |
| Lladó A et al. | Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. | 2004 | Mol. Biol. Cell | pmid:15342779 |