| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glomerulonephritis | D005921 | 35 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Löber K et al. | STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816. | 2008 | J. Cell. Biochem. | pmid:17615556 |
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| Shivshankar P et al. | Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells. | 2008 | Appl. Environ. Microbiol. | pmid:18083882 |
| Marengo B et al. | Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma. | 2008 | Free Radic. Biol. Med. | pmid:17991446 |
| Zhang H and Forman HJ | Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18048804 |
| McNally AK et al. | Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. | 2008 | Exp. Mol. Pathol. | pmid:18067888 |
| McEneaney V et al. | Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation. | 2008 | Mol. Endocrinol. | pmid:18202152 |
| Krutzik PO et al. | High-content single-cell drug screening with phosphospecific flow cytometry. | 2008 | Nat. Chem. Biol. | pmid:18157122 |
| Ramnath RD et al. | Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18160487 |
| Torricelli C et al. | Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells. | 2008 | Life Sci. | pmid:18261747 |
| Sud N et al. | Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18192589 |
| Olson ER et al. | Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts. | 2008 | Hypertension | pmid:18195168 |
| Carraway RE et al. | Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. | 2008 | Regul. Pept. | pmid:18313772 |
| Song KS et al. | Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis. | 2008 | Autophagy | pmid:18424913 |
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| Schonhoff CM et al. | Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. | 2008 | Hepatology | pmid:18273864 |
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| Rishton GM | Aggregator compounds confound amyloid fibrillization assay. | 2008 | Nat. Chem. Biol. | pmid:18277973 |
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| Lin CW et al. | Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. | 2008 | Carcinogenesis | pmid:18628248 |
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| Lee JS et al. | House dust mite, Dermatophagoides pteronissinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells. | 2008 | Cytokine | pmid:18490175 |
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| Lim JH et al. | Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-delta-independent pathway in human colon cancer cells. | 2008 | Apoptosis | pmid:18807195 |
| Kojima K et al. | Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18789895 |
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| Lima F et al. | Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. | 2009 | Mol. Biol. Cell | pmid:19339281 |
| Raghu H et al. | Kaposi's sarcoma-associated herpesvirus utilizes an actin polymerization-dependent macropinocytic pathway to enter human dermal microvascular endothelial and human umbilical vein endothelial cells. | 2009 | J. Virol. | pmid:19279100 |
| Coan KE et al. | Promiscuous aggregate-based inhibitors promote enzyme unfolding. | 2009 | J. Med. Chem. | pmid:19281222 |
| Choi YA et al. | Integrin signaling and cell spreading alterations by rottlerin treatment of chick limb bud mesenchymal cells. | 2009 | Biochimie | pmid:19306958 |
| Thrower EC et al. | Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini. | 2009 | Pancreas | pmid:19752773 |
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| Kang JH et al. | Plasma protein kinase C (PKC)alpha as a biomarker for the diagnosis of cancers. | 2009 | Carcinogenesis | pmid:19710177 |
| Gao FH et al. | Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. | 2009 | Exp. Cell Res. | pmid:19747914 |
| Lim JH et al. | Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells. | 2009 | Carcinogenesis | pmid:19037087 |
| Jang BC | Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion. | 2009 | Toxicol In Vitro | pmid:19084589 |
| Valacchi G et al. | Rottlerin: a multifaced regulator of keratinocyte cell cycle. | 2009 | Exp. Dermatol. | pmid:19492998 |
| Nguyen KT et al. | Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes. | 2009 | Neurochem. Res. | pmid:19495968 |
| Liu CY et al. | Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA. | 2009 | Biochim. Biophys. Acta | pmid:19477272 |
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| Fordjour AK and Harrington EO | PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function. | 2009 | Biochim. Biophys. Acta | pmid:19632305 |
| Fan Y et al. | Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation. | 2009 | Neurosci Bull | pmid:19633700 |
| Esper RM and Loeb JA | Neurotrophins induce neuregulin release through protein kinase Cdelta activation. | 2009 | J. Biol. Chem. | pmid:19648576 |
| Zhao M et al. | Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells. | 2009 | PLoS ONE | pmid:19662097 |
| Park SK et al. | Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. | 2009 | Carcinogenesis | pmid:19420016 |
| Matsuoka H et al. | Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways. | 2009 | Exp. Cell Res. | pmid:19393235 |
| Di Rosa M et al. | Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. | 2009 | J. Cell. Biochem. | pmid:19415692 |
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| Kato K et al. | Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells. | 2009 | Am. J. Physiol. Heart Circ. Physiol. | pmid:19837952 |
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| Maioli E et al. | Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells. | 2009 | J. Biomed. Biotechnol. | pmid:20168983 |
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| Ohno I et al. | Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19762431 |
| Lin CJ et al. | Rottlerin inhibits migration of follicular thyroid carcinoma cells by PKCdelta-independent destabilization of the focal adhesion complex. | 2010 | J. Cell. Biochem. | pmid:20225271 |
| Li X et al. | PKC-delta promotes renal tubular cell apoptosis associated with proteinuria. | 2010 | J. Am. Soc. Nephrol. | pmid:20395372 |
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| Malla N et al. | Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway. | 2011 | PLoS ONE | pmid:21673806 |
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| Valacchi G et al. | Rottlerin exhibits antiangiogenic effects in vitro. | 2011 | Chem Biol Drug Des | pmid:21435184 |
| Uruno A et al. | All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. | 2011 | J. Leukoc. Biol. | pmid:21393419 |
| Ku CS et al. | Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells. | 2011 | Nutr Res | pmid:21530801 |
| Kim YR et al. | Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation. | 2011 | Cell Biochem. Biophys. | pmid:21468691 |
| Leverence JT et al. | Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation. | 2011 | Chem. Biol. Interact. | pmid:20920494 |
| Park EJ and Kwon TK | Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. | 2011 | Exp. Mol. Med. | pmid:21971413 |
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| Matta C et al. | PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures. | 2011 | Biochimie | pmid:20850497 |
| Zhang D et al. | Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21310168 |
| Lim SC et al. | Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. | 2011 | Carcinogenesis | pmid:21362627 |
| Wermuth PJ et al. | Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. | 2011 | PLoS ONE | pmid:22096525 |